HADH
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Official Full Name
hydroxyacyl-CoA dehydrogenase -
Overview
This gene is a member of the 3-hydroxyacyl-CoA dehydrogenase gene family. The encoded protein functions in the mitochondrial matrix to catalyze the oxidation of straight-chain 3-hydroxyacyl-CoAs as part of the beta-oxidation pathway. Its enzymatic activity is highest with medium-chain-length fatty acids. Mutations in this gene cause one form of familial hyperinsulinemic hypoglycemia. The human genome contains a related pseudogene of this gene on chromosome 15. -
Synonyms
HADH;hydroxyacyl-CoA dehydrogenase;HADHSC, hydroxyacyl Coenzyme A dehydrogenase , L 3 hydroxyacyl Coenzyme A dehydrogenase, short chain;hydroxyacyl-coenzyme A dehydrogenase, mitochondrial;HADH1;SCHAD;short-chain 3-hydroxyacyl-CoA dehydrogenase;L-
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Chicken
- Mouse
- Zebrafish
- Human
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- Non
- GST
- T7
- Avi
- Fc
- DDK
- Myc
- SUMO
- Flag
Involved Pathway
HADH involved in several pathways and played different roles in them. We selected most pathways HADH participated on our site, such as Fatty acid elongation,Fatty acid degradation,Valine, leucine and isoleucine degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HADH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fatty acid degradation | ACSBG2,ALDH1B1,ALDH7A1,ALDH3A2,EHHADH,ACAA2,CYP4A14,CPT1B,ADH2-2,ACADVL |
| Fatty acid elongation | MECR,ELOVL7A,TECR,ELOVL6,HADHB,ELOVL4A,ACOT5,PPT1,ELOVL1,ACAA2 |
| Tryptophan metabolism | HAAO,INMT,ALDH7A1,IL4I1,DHCR24,AADAT,ALDH3A2,CYP4F12,CMTM2A,CAT |
| Fatty acid metabolism | ACSL5,HADHA,ELOVL5,ACSL3B,SCD5,ELOVL6,FADS2,ACAA1,HADHAA,ACACA |
| Metabolic pathways | PPAP2A,TYMS,LASS2,ALPI,PLA2G5,ALDH3A2A,ATP6V1BA,CERS4,DPAGT1,NDUFB9 |
| Lysine degradation | SETD1B,EHMT2,COLGALT2,ALDH2.2,PLOD1A,AADAT,CAMKMT,SETDB2,SUV420H1,SETD8B |
| Valine, leucine and isoleucine degradation | PCCB,AOX1,ACAT1,ACAD8,HADHAA,MUT,HIBADH,AOX3L1,HADHAB,ALDH2 |
| Butanoate metabolism | ACSM3,OXCT2,GAD1B,ACSM2B,HMGCL,ACSM5,ECHS1,HMGCS1,ABAT,BDH1 |
Protein Function
HADH has several biochemical functions, for example, 3-hydroxyacyl-CoA dehydrogenase activity,NAD+ binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HADH itself. We selected most functions HADH had, and list some proteins which have the same functions with HADH. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 3-hydroxyacyl-CoA dehydrogenase activity | HSD17B4,HADHAB,EHHADH,HSD17B10,HADHAA,H2-KE6,HSD17B8,HADHB,HADHA |
| NAD+ binding | SIRT1,SIRT3,ALDH1A3,GLUD1,SIRT2,HPGD,SIRT6,SIRT5,SIRT4,UXS1 |
Interacting Protein
HADH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HADH here. Most of them are supplied by our site. Hope this information will be useful for your research of HADH.
UBA5;ADH1A;STAT1;2_aha_camp;8-aha-camp;8-aha-omethyladenosine
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