HABP2
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Official Full Name
hyaluronan binding protein 2 -
Overview
The protein encoded by this gene is an extracellular serine protease that binds hyaluronic acid and is involved in cell adhesion. The encoded protein is synthesized as a single chain, but then undergoes an autoproteolytic event to form the functional heterodimer. Further autoproteolysis leads to smaller, inactive peptides. This protease is known to cleave urinary plasminogen activator, coagulation factor VII, and the alpha and beta chains of fibrinogen, but not prothrombin, plasminogen, or the gamma chain of fibrinogen. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
HABP2;hyaluronan binding protein 2;hyaluronan-binding protein 2;factor VII activating protein;FSAP;HABP;HGFAL;PHBP;plasma hyaluronan binding protein;Factor seven activating protease;Factor seven-activating protease;Factor VII-activating protease;HABP 2;HABP2_HUMAN;Hepatocyte growth factor activator like protein;Hepatocyte growth factor activator-like protein;Hyaluronan-binding protein 2 27 kDa light chain alternate form;Hyaluronic acid binding protein 2;Plasma hyaluronan-binding protein;OTTHUMP00000020505;hepatocyte
Recombinant Proteins
- Human
- Rat
- Chicken
- Zebrafish
- E.coli
- HEK293
- Mammalian Cell
- Wheat Germ
- Mammalian cells
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
- His&SUMO
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HABP2-20H | Recombinant Human HABP2 protein, GST-tagged | E.coli | Human | GST | C-term-389aa |
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| HABP2-21H | Recombinant Human HABP2 protein, His-tagged | HEK293 | Human | His | 1-279 a.a. |
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| HABP2-2779R | Recombinant Rat HABP2 Protein | Mammalian Cell | Rat | His |
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| HABP2-28753TH | Recombinant Human HABP2 | Wheat Germ | Human | Non | 100 amino acids |
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| HABP2-4549H | Recombinant Human HABP2 Protein, GST-tagged | Wheat Germ | Human | GST |
|
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| HABP2-4792C | Recombinant Chicken HABP2 | Mammalian Cell | Chicken | His |
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| HABP2-6142Z | Recombinant Zebrafish HABP2 | Mammalian Cell | Zebrafish | His |
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| HABP2-7850H | Recombinant Human HABP2 protein, His-tagged | E.coli | Human | His | Phe24~Phe560 |
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| HABP2-5649HCL | Recombinant Human HABP2 293 Cell Lysate | HEK293 | Human | Non |
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| HABP2-2433R | Recombinant Rat HABP2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| HABP2-2433R-B | Recombinant Rat HABP2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| HABP2-2860H | Recombinant Human HABP2 Protein (Met1-Gln279), C-His tagged | Mammalian cells | Human | His | Met1-Gln279 |
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| HABP2-2861H | Recombinant Human HABP2 Protein (Ser25-Phe560), N-His tagged | E.coli | Human | His | Ser25-Phe560 |
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| HABP2-3418HF | Recombinant Full Length Human HABP2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 560 amino acids |
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| HABP2-4391H | Recombinant Human HABP2 protein, His-SUMO-tagged | E.coli | Human | His&SUMO | 37-313aa |
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| HABP2-4392H | Recombinant Human HABP2 protein, His-SUMO-tagged | E.coli | Human | His&SUMO | 314-560aa |
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Involved Pathway
HABP2 involved in several pathways and played different roles in them. We selected most pathways HABP2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with HABP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
HABP2 has several biochemical functions, for example, glycosaminoglycan binding,serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HABP2 itself. We selected most functions HABP2 had, and list some proteins which have the same functions with HABP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| serine-type endopeptidase activity | PLAUB,PRSS52,PARL,CLPP,F7I,PRSS59.2,Gzmg,KLK2,TMPRSS12,TPSAB1 |
| glycosaminoglycan binding | SPOCK2,VCAN,VIT,TGFBR2,PODXL2,SERPINE2,EPYC,NDNF,Shh,SERPINA5 |
Interacting Protein
HABP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HABP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HABP2.
PARP2
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References
- Iida, J; Dorchak, J; et al. Role for chondroitin sulfate glycosaminoglycan in NEDD9-mediated breast cancer cell growth. EXPERIMENTAL CELL RESEARCH 330:358-370(2015).
- Arif, M; Thakur, SC; et al. Disrupted hyaluronan binding protein 1 (HABP1) expression: one of the key mediator for ovarian dysfunction in polycystic ovary rat. MOLECULAR AND CELLULAR BIOCHEMISTRY 398:233-244(2015).
