GTF2A1
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Official Full Name
general transcription factor IIA, 1, 19/37kDa -
Overview
Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II;(POLR2A; MIM 180660) and several general initiation factors (summarized by DeJong and Roeder, 1993 (PubMed 8224848)).;One of these factors is TFIIA, which when purified from HeLa extracts consists of 35-, 19-, and 12-kD;subunits. -
Synonyms
GTF2A1;general transcription factor IIA, 1, 19/37kDa;glucose regulated protein, 58kD pseudogene;transcription initiation factor IIA subunit 1;TFIIA;General transcription factor IIA 1 19/37kDa;General transcription factor IIA1;Glucose regulated protein 58kD pseudogene;TF2A1;TFIIA 42;TFIIA alpha p55;TFIIA alpha p55, isoform 1;TFIIAL;TFIIA-42;OTTHUMP00000245978;OTTHUMP00000245980;TFIIA alpha, p55, isoform 1;general transcription factor IIA subunit 1;transcription initiation factor TFIIA 42
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Rat
- Chicken
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- Non
- His
- His&GST
- His&Fc&Avi
Involved Pathway
GTF2A1 involved in several pathways and played different roles in them. We selected most pathways GTF2A1 participated on our site, such as Basal transcription factors,Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GTF2A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Viral carcinogenesis | HIST3H2BB-PS,DLG1,PIK3CB,SP100,NFKBIA,HLA-B,DDX3X,MAPK1,IRF3,Casp3 |
| Basal transcription factors | TAF12,GTF2H4,GTF2B,MNAT1,GTF2H2C,GTF2I,GTF2H3-2,GTF2E2,TBPL2,TAF2 |
Protein Function
GTF2A1 has several biochemical functions, for example, DNA binding,TBP-class protein binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GTF2A1 itself. We selected most functions GTF2A1 had, and list some proteins which have the same functions with GTF2A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription coactivator activity | TAF11,SUPT7L,PML,JUN,MED21,TAF7,CITED1,RXRA,MED14,TFDP1 |
| protein heterodimerization activity | WHRN,CEBPA,HIST3H2BB,USF2,MCL1B,TXLNG,SLC51A,ANO9A,KCNB2,DRAP1 |
| transcription factor binding | PPARGC1A,HDAC8,HES4,TRAPPC2,KCNA3,HAND1,ENPP2,TRIM6,E2F1,HTT |
| DNA binding | HIST1H47,CDX1A,HDGF2,EN2,SSH1,IFIH1,ZNF184,H2AFX,ZNF222,HOXB9A |
| protein binding | RRS1,GRB2,NFU1,GRIK5,SEPT9,ALKBH3,NOXO1,ADM,TRPV4,BSX |
| TBP-class protein binding | TAF1B,PSMC1B,PSMC1,GTF2A2,TAF1,TAF1L,HHEX,PSMC5,BRF1A,DR1 |
Interacting Protein
GTF2A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GTF2A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GTF2A1.
GTF2A2;TBPL1;NFYA;TBP;SCHIP1;CREB1;Tbpl1
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