GSTZ1
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Official Full Name
glutathione transferase zeta 1 -
Overview
This gene is a member of the glutathione S-transferase (GSTs) super-family which encodes multifunctional enzymes important in the detoxification of electrophilic molecules, including carcinogens, mutagens, and several therapeutic drugs, by conjugation with glutathione. This enzyme also plays a significant role in the catabolism of phenylalanine and tyrosine. Thus defects in this enzyme may lead to severe metabolic disorders including alkaptonuria, phenylketonuria and tyrosinaemia. Several transcript variants of this gene encode multiple protein isoforms. -
Synonyms
GSTZ1;glutathione transferase zeta 1;maleylacetoacetate isomerase;GSTZ1 1;MAAI;MAI;EC 2.5.1.18;EC 5.2.1.2;Glutathione S transferase zeta 1;GSTZ1-1;OTTHUMP00000246405;OTTHUMP00000246406;OTTHUMP00000246407;OTTHUMP00000246408;OTTHUMP00000246409;OTTHUMP00000246410;OTTHUMP00000246413;maleylacetone isomerase;glutathione S-aryltransferase;glutathione S-alkyltransferase;glutathi
Recombinant Proteins
- Human
- Rat
- Chicken
- Cynomolgus
- Zebrafish
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
GSTZ1 involved in several pathways and played different roles in them. We selected most pathways GSTZ1 participated on our site, such as Tyrosine metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with GSTZ1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Tyrosine metabolism | AOX2P,GOT2A,TAT,AOX3,FAH,ALDH1A3,DCT,COMTB,ADH1,AOC2 |
| Metabolic pathways | UGT1A1,ACSL4B,POLR2K,SAT1A.2,HSD17B12B,RPIA,ADH1,SYNJ2,PKLR,RDH8B |
Protein Function
GSTZ1 has several biochemical functions, for example, glutathione peroxidase activity,glutathione transferase activity,maleylacetoacetate isomerase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GSTZ1 itself. We selected most functions GSTZ1 had, and list some proteins which have the same functions with GSTZ1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | EMP1,FBXO46,RNF20,DRAM1,TXNL4A,PDPK1,UPK3A,ERLEC1,FAS,DARS2 |
| glutathione transferase activity | LTC4S,GSTT2,GSTM,GRX2,GSTA4,GSTA1,GSTA,MGST3,GDAP1L1,GSTAL |
| protein homodimerization activity | ROPN1B,Trl,S100B,ANG,HHEX,ENO2,CRTAM,XBP1,TFAP4,ABCD2 |
| glutathione peroxidase activity | GPX1A,GPX1,MGST1,GPX4B,MGST2,LTC4S,GPX1B,GPX5,CLIC2,GPX3 |
Interacting Protein
GSTZ1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GSTZ1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GSTZ1.
ABL1;FYN;NCK1;GRB2;PPP1CC
Resources
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References
- Sappl, PG; Onate-Sanchez, L; et al. Proteomic analysis of glutathione S-transferases of Arabidopsis thaliana reveals differential salicylic acid-induced expression of the plant-specific phi and tau classes. PLANT MOLECULAR BIOLOGY 54:205-219(2004).
- Nadal-Wollbold, F; Pawlowski, M; et al. Platelet ERK2 activation by thrombin is dependent on calcium and conventional protein kinases C but not Raf-1 or B-Raf. FEBS LETTERS 531:475-482(2002).
