GSTP1
-
Official Full Name
glutathione S-transferase pi 1 -
Overview
Glutathione S-transferases (GSTs) are a family of isoenzymes that detoxify electrophiles through conjugation to thiol-reduced glutathione (GSH). Thus, they are critical in protecting cells from toxins (drugs, pesticides, carcinogens) and oxidative stress -
Synonyms
GSTP1;glutathione S-transferase pi 1;FAEES3, GST3;glutathione S-transferase P;GSTP;GSTP1-1;GST class-pi;deafness, X-linked 7;fatty acid ethyl ester synthase III;PI;DFN7;GST3;FAEES3
Recombinant Proteins
- Human
- Cattle
- Rat
- Rhesus macaque
- Mouse
- Cynomolgus
- Zebrafish
- Hamster
- Chinese hamster
- Long-tailed dwarf hamster
- E.coli
- Human
- Mammalian Cell
- Wheat Germ
- HEK293
- Mammalian cells
- Yeast
- Insect Cell
- In Vitro Cell Free System
- HEK293T
- E. coli
- His
- HIS
- Non
- GST
- His&Strep
- His&Fc&Avi
- Flag
- His&Myc
- N-10xHis
- N-6xHis
- Myc&DDK
- His&SUMO
Involved Pathway
GSTP1 involved in several pathways and played different roles in them. We selected most pathways GSTP1 participated on our site, such as Glutathione metabolism,Metabolism of xenobiotics by cytochrome P,Drug metabolism - cytochrome P, which may be useful for your reference. Also, other proteins which involved in the same pathway with GSTP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism of xenobiotics by cytochrome P | GSTT2,DHDH,SULT2A1,HSD11B1,UGT2A3,EPHX1,ALDH3B2,ALDH1A3,GSTA4,GSTP2 |
| Prostate Cancer | TCF7,SMARCD1,FGFR1,PIK3CD,SPRY1,MAP2K2,RB1,SMARCC2,SOS1,AKT1 |
| Pathways in cancer | WNT8A,RAC3,PML,FGFR2,VEGFC,GNG11,RHOA,RALB,APC2,TRAF3 |
| Chemical carcinogenesis | CYP2C9,CYP2C8,CYP3A41A,UGT1A7,ADH1C,GSTA2,HSD11B1,ALDH3B1,GSTK1,ALDH3A1 |
| Drug metabolism - cytochrome P | MGST1,MGST1.2,UGT1A4,GSTP2,MGST3,GSTA3,AOX3L1,UGT1AB,FMO2,GSTA2 |
| Glutathione metabolism | GPX3,GGCTA,GGT1A,GGT5,G6PDX,GSTM2,MGST3,GSTM6,GPX7,GSTO1 |
Protein Function
GSTP1 has several biochemical functions, for example, JUN kinase binding,S-nitrosoglutathione binding,dinitrosyl-iron complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GSTP1 itself. We selected most functions GSTP1 had, and list some proteins which have the same functions with GSTP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | FAM118A,CARD8,SKP1,RAB3C,YY1A,USP5,SMIM3,FLRT3,KCNJ4,IFIT2 |
| dinitrosyl-iron complex binding | GSTP2 |
| S-nitrosoglutathione binding | GSTP2 |
| JUN kinase binding | PTK2,MAPK8IP3,MAD2L2,SPAG9A,SPAG9 |
| glutathione transferase activity | GSTA,GSTZ1,GSTM4,GSTA4,EEF1E1,GSTT2B,GSTM,GSTM1,LTC4S,GSTM6 |
| kinase regulator activity | BCCIP |
| nitric oxide binding | CBS |
Interacting Protein
GSTP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GSTP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GSTP1.
TRAF2;KRTAP10-7;KRTAP10-9;KRT31;NOTCH2NL
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References
- Banerjee, J; Mishra, R; et al. A reciprocal role of prostate cancer on stromal DNA damage. ONCOGENE 33:4924-4931(2014).
- Yamamoto, Y; Konishi, H; et al. Significance of GSTP1 for predicting the prognosis and chemotherapeutic efficacy in esophageal squamous cell carcinoma. ONCOLOGY REPORTS 30:1687-1694(2013).
