GRIK1
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Official Full Name
glutamate receptor, ionotropic, kainate 1 -
Overview
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. -
Synonyms
GRIK1;glutamate receptor, ionotropic, kainate 1;GLUR5;glutamate receptor, ionotropic kainate 1;GluK1;gluR-5;glutamate receptor 5;excitatory amino acid receptor 3;EAA3;EEA3;GLR5
Recombinant Proteins
- Rat
- Human
- Cynomolgus
- Mammalian Cell
- Wheat Germ
- HEK293
- E.coli
- His
- Non
- His&Fc&Avi
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GRIK1-2695R | Recombinant Rat GRIK1 Protein | Mammalian Cell | Rat | His |
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| GRIK1-28537TH | Recombinant Human GRIK1 | Wheat Germ | Human | Non | 110 amino acids |
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| GRIK1-566C | Recombinant Cynomolgus GRIK1 Protein, His-tagged | Mammalian Cell | Cynomolgus | His |
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| GRIK1-2349R | Recombinant Rat GRIK1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| GRIK1-2349R-B | Recombinant Rat GRIK1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| GRIK1-2748H | Recombinant Human GRIK1 protein(291-530 aa), C-His-tagged | E.coli | Human | His | 291-530 aa |
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| GRIK1-312C | Recombinant Cynomolgus Monkey GRIK1 Protein, His (Fc)-Avi-tagged | HEK293 | Cynomolgus | His&Fc&Avi |
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| GRIK1-312C-B | Recombinant Cynomolgus Monkey GRIK1 Protein Pre-coupled Magnetic Beads | HEK293 | Cynomolgus |
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| GRIK1-5336H | Recombinant Human GRIK1 Protein, GST-tagged | Wheat Germ | Human | GST |
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Involved Pathway
GRIK1 involved in several pathways and played different roles in them. We selected most pathways GRIK1 participated on our site, such as Neuroactive ligand-receptor interaction,Glutamatergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRIK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuroactive ligand-receptor interaction | TAAR14F,DRD4B,GLRA3,CHRNB3B,CHRM2A,CRHR2,FPR2,F2RL1.2,GRM8,TACR3L |
| Glutamatergic synapse | GNG7,GRM3,GNB3,GNAI2,GNG13,GRIN2B,GNB1,GNAS,GNGT1,GNG12 |
Protein Function
GRIK1 has several biochemical functions, for example, drug binding,extracellular-glutamate-gated ion channel activity,glutamate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GRIK1 itself. We selected most functions GRIK1 had, and list some proteins which have the same functions with GRIK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| voltage-gated cation channel activity | GRIN1,HVCN1,PKD2,GRIN2A |
| drug binding | PPARA,ACE,PYGL,HMGB2,Alb,SRP54B,TOP2A,DHODH,HTR2C,CYP2D6 |
| kainate selective glutamate receptor activity | GRIK4,GRIK5,GRIK2,GRIK3 |
| protein homodimerization activity | GNPTG,CEACAM1,GCH1,COQ9,EFR3A,TNNC1,MAPK4,DMRT3,PDGFB,SMAGP |
| glutamate binding | SLC1A3,GCLC,GRM7,GAD2,SLC1A1,GLUL,GRIN1,GRIN2A,CPS1 |
| extracellular-glutamate-gated ion channel activity | GRIN2D,GRIA4B,GRIK3,GRIA3A,GRIN3B,GRIN1B,GRIA1B,GRIN2B,GRIA4A,GRIA1 |
Interacting Protein
GRIK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRIK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRIK1.
Resources
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References
- Kranzler, HR; Armeli, S; et al. GRIK1 Genotype and Daily Expectations of Alcohol's Positive Effects Moderate the Reduction of Heavy Drinking by Topiramate. EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY 22:494-501(2014).
- Kranzler, HR; Wetherill, R; et al. Posttreatment Effects of Topiramate Treatment for Heavy Drinking. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 38:3017-3023(2014).
