GPSM1

  • Official Full Name

    G-protein signaling modulator 1

  • Overview

    G-protein signaling modulators (GPSM) play diverse functional roles through their interaction with G-protein subunits. This gene encodes a receptor-independent activator of G protein signaling, which is one of several factors that influence the basal activity of G protein signaling systems. The protein contains seven tetratricopeptide repeats in its N-terminal half and four G-protein regulatory (GPR) motifs in its C-terminal half. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

  • Synonyms

    GPSM1;G-protein signaling modulator 1;G protein signalling modulator 1 (AGS3 like, C. elegans);G-protein-signaling modulator 1;AGS3;AGS3 homolog (C. elegans);DKFZP727I051;Activator of G-protein signaling 3;AGS3 homolog;C10a;G protein signaling modulator 1 (AGS3 like, C. elegans);GPSM1_HUMAN;1810037C22Rik;G-protein signaling modulator 1 (AGS3-like, C. elegans);G-protein signalling modulator 1 (AGS3-like, C. elegans)

Recombinant Proteins

  • Rat
  • Mouse
  • Human
  • Mammalian Cell
  • HEK293
  • HEK293T
  • Wheat Germ
  • In Vitro Cell Free System
  • His
  • Non
  • Myc&DDK
  • His&Fc&Avi
  • GST

    Involved Pathway

    GPSM1 involved in several pathways and played different roles in them. We selected most pathways GPSM1 participated on our site, such as Cocaine addiction, which may be useful for your reference. Also, other proteins which involved in the same pathway with GPSM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cocaine addiction SLC18A1,DDC,GRIN2A,CDK5,FOSB,GRIN2C,MAOB,CREB3L2,GRIN2B,GNAI1

    Protein Function

    GPSM1 has several biochemical functions, for example, GDP-dissociation inhibitor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GPSM1 itself. We selected most functions GPSM1 had, and list some proteins which have the same functions with GPSM1. You can find most of the proteins on our site.

    Function Related Protein
    protein binding ZBTB49,GNPDA1,ALDH3A1,ZSCAN12,NIPAL1,ASNS,RPUSD3,PAWR,RUSC1,RAD9
    GDP-dissociation inhibitor activity RANBP1,SH3BP4A,GPSM1B,RGS14,SH3BP4,ITGB1BP1,GPSM2L,GDI1

    Interacting Protein

    GPSM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GPSM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GPSM1.

    ZBED1;DAZAP2;TRIP13;CCDC158;USHBP1

    Resources

    References

    • Giguere, PM; Billard, MJ; et al. G-protein signaling modulator-3, a gene linked to autoimmune diseases, regulates monocyte function and its deficiency protects from inflammatory arthritis. MOLECULAR IMMUNOLOGY 54:193-198(2013).
    • Sugihara, M; Morita, H; et al. Dual Signaling Pathways of Arterial Constriction by Extracellular Uridine 5 '-Triphosphate in the Rat. JOURNAL OF PHARMACOLOGICAL SCIENCES 115:293-308(2011).

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