GPRC5B
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Official Full Name
G protein-coupled receptor, family C, group 5, member B -
Overview
The protein encoded by this gene is a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The specific function of this protein is unknown; however, this protein may mediate the cellular effects of retinoic acid on the G protein signal transduction cascade. -
Synonyms
GPRC5B;G protein-coupled receptor, family C, group 5, member B;G protein coupled receptor, family C, group 1, member B;G-protein coupled receptor family C group 5 member B;RAIG 2;A-69G12.1;retinoic acid-induced gene 2 protein;retinoic acid responsi
Recombinant Proteins
- Human
- Mus musculus
- E.coli
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- E.coli expression system
- GST
- Non
- His
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GPRC5B-1846H | Recombinant Human GPRC5B protein, GST-tagged | E.coli | Human | GST | 293-331 aa | |
| GPRC5B-5770HCL | Recombinant Human GPRC5B 293 Cell Lysate | HEK293 | Human | Non |
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| GPRC5B-5285H | Recombinant Human GPRC5B Protein | Wheat Germ | Human | Non |
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| GPRC5B-5286H | Recombinant Human GPRC5B Protein, GST-tagged | Wheat Germ | Human | GST |
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| GPRC5B-5538HF | Recombinant Full Length Human GPRC5B Protein | In Vitro Cell Free System | Human | Full L. 473 amino acids |
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| GPRC5B-5544HF | Recombinant Full Length Human GPRC5B Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 29-403 amino acids |
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| RFL33569MF | Recombinant Full Length Mouse G-Protein Coupled Receptor Family C Group 5 Member B(Gprc5B) Protein, His-Tagged | E.coli expression system | Mus musculus | His | Full L. Full Length of Mature Protein (29-410) |
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| RFL406HF | Recombinant Full Length Human G-Protein Coupled Receptor Family C Group 5 Member B(Gprc5B) Protein, His-Tagged | E.coli expression system | Human | His | Full L. Full Length of Mature Protein (29-403) |
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Involved Pathway
GPRC5B involved in several pathways and played different roles in them. We selected most pathways GPRC5B participated on our site, such as GPCRs, Class C Metabotropic glutamate, pheromone, which may be useful for your reference. Also, other proteins which involved in the same pathway with GPRC5B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| GPCRs, Class C Metabotropic glutamate, pheromone | GPRC5A,GPRC5C,CASR,GPRC5D |
Protein Function
GPRC5B has several biochemical functions, for example, G-protein coupled receptor activity,G-protein coupled receptor binding,protein kinase activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GPRC5B itself. We selected most functions GPRC5B had, and list some proteins which have the same functions with GPRC5B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein coupled receptor binding | S1PR2,STUB1,ADORA1,GNA11B,USP20,RSPO1,S1PR1,GNA15.4,GNA13B,GNAV1 |
| protein kinase binding | MAP3K5,STK11IP,TRP53,CCND3,MAP2K3,YWHAZ,SOCS1,ZBTB4,EEF1A1,MSN |
| G-protein coupled receptor activity | GRM2,TAS2R104,GPR22,TAAR11,MTNR1BB,OR2J3,FZD7A,NPFFR2,TAS2R137,NPFFR1L3 |
| protein kinase activator activity | STRADA,DUSP19,DAXX,NKX3,PIK3CA,MT3,MAPK8IP2,DBF4B,FGF13,NKX3-1 |
Interacting Protein
GPRC5B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GPRC5B here. Most of them are supplied by our site. Hope this information will be useful for your research of GPRC5B.
C11orf71
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References
- Hippe, HJ; Freundt, G; et al. Orphan receptor GPRC5b activates inflammatory signaling in vascular smooth muscle cells. EUROPEAN HEART JOURNAL 35:1024-1024(2014).
- Hinney, A; Albayrak, O; et al. Genetic Variation at the CELF1 (CUGBP, Elav-Like Family Member 1 Gene) Locus is Genome-Wide Associated With Alzheimer's Disease and Obesity. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 165:283-293(2014).
