GPR161
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Official Full Name
G protein-coupled receptor 161 -
Overview
Upon ligand binding, G protein-coupled receptors, such as GPR161, activate cytoplasmic G proteins (see GNAS, MIM;139320), allowing the receptors to transduce extracellular signals across the plasma membrane into the cell.;Phosphorylation of the receptor attenuates signaling (Matteson et al., 2008 (PubMed 18250320)). -
Synonyms
GPR161;G protein-coupled receptor 161;G-protein coupled receptor 161;RE2;G protein coupled receptor 161;G protein coupled receptor RE2;OTTHUMP00000032586;OTTHUMP00000032587;G-protein coupled receptor RE2
Recombinant Proteins
- Human
- Zebrafish
- Bovine
- zebrafish
- Mus musculus
- Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
- E.coli
- Mammalian Cell
- Wheat Germ
- In Vitro Cell Free System
- E.coli expression system
- His
- GST
- Non
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GPR161-3869H | Recombinant Human GPR161 protein, His-tagged | E.coli | Human | His | 321-529 aa | |
| GPR161-1665Z | Recombinant Zebrafish GPR161 | Mammalian Cell | Zebrafish | His |
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| GPR161-1201H | Recombinant Human GPR161 Protein (1-28 aa), GST-tagged | E.coli | Human | GST | 1-28 aa |
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| GPR161-5204H | Recombinant Human GPR161 Protein | Wheat Germ | Human | Non |
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| GPR161-5205H | Recombinant Human GPR161 Protein, GST-tagged | Wheat Germ | Human | GST |
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| GPR161-5471HF | Recombinant Full Length Human GPR161 Protein | In Vitro Cell Free System | Human | Full L. 212 amino acids |
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| RFL12413BF | Recombinant Full Length Bovine G Protein-Coupled Receptor 161(Gpr161) Protein, His-Tagged | E.coli expression system | Bovine | His | Full L. Full Length (1-528) |
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| RFL12517HF | Recombinant Full Length Human G-Protein Coupled Receptor 161(Gpr161) Protein, His-Tagged | E.coli expression system | Human | His | Full L. Full Length (1-529) |
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| RFL13469DF | Recombinant Full Length Danio Rerio G-Protein Coupled Receptor 161(Gpr161) Protein, His-Tagged | E.coli expression system | zebrafish | His | Full L. Full Length (1-526) |
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| RFL22940MF | Recombinant Full Length Mouse G-Protein Coupled Receptor 161(Gpr161) Protein, His-Tagged | E.coli expression system | Mus musculus | His | Full L. Full Length (1-545) |
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| RFL7054XF | Recombinant Full Length Xenopus Tropicalis G-Protein Coupled Receptor 161(Gpr161) Protein, His-Tagged | E.coli expression system | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | His | Full L. Full Length (1-518) |
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Involved Pathway
GPR161 involved in several pathways and played different roles in them. We selected most pathways GPR161 participated on our site, such as Hedgehog off state,Hedgehog on state,Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with GPR161 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hedgehog on state | GAS8,EFCAB7,SPOP,EVC2,BOC,IQCE,MKS1,IFT172,KIF7,CDC73 |
| Hedgehog off state | IFT52,BBS13,INTU,KIF7,IFT122,WDR19,OFD1,IFT172,KIF3A,IFT88 |
| Signaling by Hedgehog | KIF7,IFT52,SCUBE2,HHAT,DZIP1,SPOPL,TTC21B,NOTUM,TULP3,WDR19 |
| Signal Transduction | ARHGAP15,AES,OTUD7B,LINGO1B,GAL,RGS7,RLBP1B,RDH14A,NMBA,SHRPRBCK1R |
Protein Function
GPR161 has several biochemical functions, for example, G-protein coupled amine receptor activity,G-protein coupled receptor activity,signal transducer activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GPR161 itself. We selected most functions GPR161 had, and list some proteins which have the same functions with GPR161. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein coupled receptor activity | GPR31B,OLFCQ19,RXFP2A,HTR1AB,GPR179,OPN1SW,TAAR7B,F2R,PPYR1,LPAR4 |
| G-protein coupled amine receptor activity | DRD4-RS,DRD5,TAAR4,DRD4,DRD4A,TAAR13C,TAAR6,TAAR7F,TAAR8B,TAAR2 |
| signal transducer activity | GNRHR3,OLFCG4,ECM1,HCAR1-2,RGS7,OLFR154,GOLT1B,OLFR476,FPR-RS6,TAS2R107 |
Interacting Protein
GPR161 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GPR161 here. Most of them are supplied by our site. Hope this information will be useful for your research of GPR161.
Resources
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References
- Feigin, ME; Xue, B; et al. G-protein-coupled receptor GPR161 is overexpressed in breast cancer and is a promoter of cell proliferation and invasion. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:4191-4196(2014).
- Laffray, S; Bouali-Benazzouz, R; et al. Impairment of GABAB receptor dimer by endogenous 14-3-3 zeta in chronic pain conditions. EMBO JOURNAL 31:3239-3251(2012).
