GNB2L1

  • Official Full Name

    guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
  • Overview

    Seems to bind protein kinase C acting as an intracellular receptor to anchor the activated PKC to the cytoskeleton. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and ITGB1, serves as a platform for SRC activation or inactivation. May play an important role in the developing brain and neuronal differentiation.
  • Synonyms

    GNB2L1;guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1;guanine nucleotide-binding protein subunit beta-2-like 1;Gnb2 rs1;H12.3;RACK1;Receptor for Activated C Kinase 1;lung cancer oncogene 7;proliferation-inducing gene 21;human lung cancer oncogene 7 protein;receptor of activated protein kinase C 1;cell proliferation-inducing gene 21 protein;guanine nucleotide-binding protein subunit beta-like protein 12.3;protein homologous to chicken B complex protein, guanine nucleotide binding;HLC-7;PIG21;Gnb2-rs1

Recombinant Proteins

  • Human
  • Chicken
  • Mouse
  • Zebrafish
  • E.coli
  • Mammalian Cells
  • HEK293
  • His
  • MBP
  • Non
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
GNB2L1-2655H Recombinant Human GNB2L1 protein, His-tagged E.coli Human His 131-317 aa
GNB2L1-1197C Recombinant Chicken GNB2L1 Mammalian Cells Chicken His
GNB2L1-1375H Recombinant Human Guanine Nucleotide-Binding Protein Subunit Beta-2-Like 1, His-tagged E.coli Human His
GNB2L1-30327TH Recombinant Human GNB2L1, His-tagged E.coli Human His Full L.
GNB2L1-465H Recombinant Human GNB2L1 protein, His&MBP-tagged E.coli Human His&MBP Met1-Arg317
GNB2L1-7028M Recombinant Mouse GNB2L1 Protein Mammalian Cells Mouse His
GNB2L1-9012Z Recombinant Zebrafish GNB2L1 Mammalian Cells Zebrafish His
GNB2L1-5862HCL Recombinant Human GNB2L1 293 Cell Lysate HEK293 Human Non
GNB2L1-3767M Recombinant Mouse GNB2L1 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
GNB2L1-3767M-B Recombinant Mouse GNB2L1 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    GNB2L1 involved in several pathways and played different roles in them. We selected most pathways GNB2L1 participated on our site, such as Androgen receptor signaling pathway,BDNF signaling pathway,CXCR4-mediated signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with GNB2L1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Interferon type I PIAS3
    CXCR4-mediated signaling events GNA13,ARR3,CFL1,CSK,CRK,ADRBK1,BLK,JAK2,MAPKAP1,PAG1
    IL-3 Signaling Pathway BMX,KCNIP3,GATA1,CISH,KCNIP3B,SPI1B,BIRC5A,GSK3AB,GATA2A,PILRB
    Androgen receptor signaling pathway DAXX,CDKN1A,EFCAB6,TGFB1I1,KAT5,PIAS3,RANBP9,SMARCE1,RNF4,ZMIZ1
    Hypoxic and oxygen homeostasis regulation of HIF-1-alpha HIF1AN,HIF3A,NAA10,COPS5
    Death Receptor Signalling TAX1BP1B,OTUD7B,OTULIN,RNF31,USP4,USP2,TAB1,SHRPRBCK1R,OTULINB,RBCK1
    IGF1 pathway GRB10
    BDNF signaling pathway YBX1,EIF4EBP1,FRS2,DOK5,CFL1,EIF2S1,JAK2,CSNK2A1,CSNK2A1P,CDK5

    Protein Function

    GNB2L1 has several biochemical functions, for example, SH2 domain binding,cysteine-type endopeptidase activator activity involved in apoptotic process,enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GNB2L1 itself. We selected most functions GNB2L1 had, and list some proteins which have the same functions with GNB2L1. You can find most of the proteins on our site.

    Function Related Protein
    protein phosphatase binding SNX3,TP53,ROS1,Itga10&Itgb1,HSP90B1,PPARG,CDH5,MVP,PIK3R1,STAT6
    protein kinase C binding SDC4,CASQ2,HAND2,AKT1,PKN1,TDG,TWF2,PKP2,LDB3,SDPRB
    SH2 domain binding CTR9,LILRB1,SIT1,SHCBP1,PAG1,LAX1,PTK2,JAK2,TRPV4,SQSTM1
    protein tyrosine kinase inhibitor activity IBTK,FGFR1OP
    receptor tyrosine kinase binding TOB1,ZNF259,SQSTM1,PLCG1,FNTA,GAS6,SHC4,ARHGEF16,Flt3l,PITPNM3
    receptor binding CSK,UCN2,FGF8B,TNFSF8,MCHR1,ACOT2,PIPOX,FGF1A,RIPK2,FGF13A
    protein binding NIPBL,HHIP,BID,HIST1H2BB,FKBP2,AVPR1A,NSMCE2,DVL1,TRAF3IP1,REPS1
    ion channel inhibitor activity PDZD3,KCNMB2,KCNV1,RSC1A1,ENSA,STOML1
    protein homodimerization activity IZUMO1,SYT14,CRYAB,RASGRP1,FLT3LG,HAND1,ZHX3,BCL2L10,HRSP12,CEP57

    Interacting Protein

    GNB2L1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GNB2L1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GNB2L1.

    DYNLL1;VHL;PPID;bzlf1_ebvb9

    Resources

    References

    • Guiry, A; Flynn, D; et al. Testes and brain gene expression in precocious male and adult maturing Atlantic salmon (Salmo salar). BMC GENOMICS 11:-(2010).
    • Sun, Y; Tao, Y; et al. The schizophrenia/bipolar disorder candidate gene GNB1L is regulated in human temporal cortex by a cis-acting element located within the 3'-region. NEUROSCIENCE BULLETIN 31:43-52(2015).

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