GLB1
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Official Full Name
galactosidase, beta 1 -
Overview
This gene encodes beta-galactosidase-1, a lysosomal enzyme that hydrolyzes the terminal beta-galactose from ganglioside substrates and other glycoconjugates. Defects in this gene are the cause of GM1-gangliosidosis and Morquio B syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
GLB1;galactosidase, beta 1;elastin receptor 1 (67kD) , elastin receptor 1, 67kDa , ELNR1;beta-galactosidase;EBP;Acid beta galactosidase;Acid beta-galactosidase;Beta galactosidase;BGAL_HUMAN;Elastin receptor 1 (67kD);Elastin receptor 1 67kDa;Elastin receptor 1;ELNR1;Galactosidase beta 1;GLB 1;Lactase;OTTHUMP00000208610;OTTHUMP00000208611;OTTHUMP00000208612;elastin receptor 1, 67kDa;MPS4B
Recombinant Proteins
- Human
- Mouse
- Rat
- Zebrafish
- Chicken
- E.coli
- HEK293
- CHO
- Mammalian Cells
- Wheat Germ
- In Vitro Cell Free System
- His
- His&GST
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
- GST
Involved Pathway
GLB1 involved in several pathways and played different roles in them. We selected most pathways GLB1 participated on our site, such as Galactose metabolism,Other glycan degradation,Glycosaminoglycan degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with GLB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycosphingolipid biosynthesis - ganglio series | SLC33A1,B3GALT4,ST6GALNAC6,ST8SIA5,ST3GAL2,ST3GAL1,B4GALNT1,HEXA,ST8SIA1,ST3GAL5 |
| Metabolic pathways | LASS4,DHRS9,BTD,NDUFA4L,FUT7,SMPD1,PAFAH1B2,PAPSS1,GFPT2,PPCDC |
| Galactose metabolism | HKDC1,G6PCA.2,UGP2B,PGM2,LCT,B4GALT1,G6PC,GALM,AKR1B10,PFKM |
| Sphingolipid metabolism | ACER1,SPTLC2A,GLTPA,ASAH1,B4GALT6,ARSE,LASS4,GALC,PPM1L,NEU2 |
| Glycosaminoglycan degradation | GALNS,GUSB,HGSNAT,GNS,HPSE,SPAM1,HYAL3,NAGLU,HYAL1,GNSB |
| Other glycan degradation | FUCA1.2,NEU3,HEXDC,MAN2C1,AGA,NEU3.1,MANBA,GBA2,NEU1,NEU3.3 |
| Lysosome | DNASE2,LGMN,NAGPA,AP1S3B,CTSZ,ATP6V0CB,CTSO,ENTPD4,GALCB,HYAL1 |
Protein Function
GLB1 has several biochemical functions, for example, beta-galactosidase activity,galactoside binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GLB1 itself. We selected most functions GLB1 had, and list some proteins which have the same functions with GLB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| beta-galactosidase activity | GBA3,GLB1L3,GLB1L2,GLB1L |
| protein binding | GOLGA2,ODF2,MRC1,HTR6,CEBPG,ORAI3,PITX2,TP73,SLC9A7,LONP1 |
| galactoside binding | LGALS2B,LGALS9L1,LGALS3L,LGALS2A,LGALS1L1,LGALS2,GLA |
Interacting Protein
GLB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GLB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GLB1.
CTNNBIP1;FOS;TK1;PLK1;CSNK2B;NEU1;A2M;cona_canen;ELN;H2AFX
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