GGCX
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Official Full Name
gamma-glutamyl carboxylase -
Overview
This gene encodes an enzyme which catalyzes the posttranslational modification of vitamin K-dependent protein. Many of these vitamin K-dependent proteins are involved in coagulation so the function of the encoded enzyme is essential for hemostasis. Mutations in this gene are associated with vitamin K-dependent coagulation defect and PXE-like disorder with multiple coagulation factor deficiency. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
GGCX;gamma-glutamyl carboxylase;vitamin K-dependent gamma-carboxylase;vitamin K dependent gamma carboxylase;VKCFD1;FLJ26629;Gamma glutamyl carboxylase;GC;Peptidyl glutamate 4 carboxylase;Peptidyl-glutamate 4-carboxylase;Vitamin K gamma glutamyl carboxylase;VKCFD 1;VKGC_HUMAN;OTTHUMP00000160676;OTTHUMP00000203090
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Mus musculus
- Sheep
- Pongo Abelii
- Delphinapterus leucas (Beluga whale)
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- Insect Cell
- E.coli expression system
- GST
- His
- Non
- Flag
- His&Fc&Avi
Involved Pathway
GGCX involved in several pathways and played different roles in them. We selected most pathways GGCX participated on our site, such as Ubiquinone and other terpenoid-quinone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GGCX were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ubiquinone and other terpenoid-quinone biosynthesis | VKORC1L1,COQ6,COQ5,COQ3,HPDA,COQ7,TAT,HPDB,HPD,COQ2 |
Protein Function
GGCX has several biochemical functions, for example, gamma-glutamyl carboxylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GGCX itself. We selected most functions GGCX had, and list some proteins which have the same functions with GGCX. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| gamma-glutamyl carboxylase activity | PDXDC1 |
Interacting Protein
GGCX has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GGCX here. Most of them are supplied by our site. Hope this information will be useful for your research of GGCX.
Mgp;AP1S2;Ncstn;Tubg1;Smn1;FGD1;Anapc2;Cdc16;FAM46A;Mad2l1bp;TERF2IP
Resources
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References
- Sun, YF; Wu, ZT; et al. Impact of gamma-glutamyl carboxylase gene polymorphisms on warfarin dose requirement: A systematic review and meta-analysis. THROMBOSIS RESEARCH 135:739-747(2015).
- Kumar, DK; Shewade, DG; et al. An acenocoumarol dosing algorithm exploiting clinical and genetic factors in South Indian (Dravidian) population. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY 71:173-181(2015).
