GFM1
-
Official Full Name
G elongation factor, mitochondrial 1 -
Overview
Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain-oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA. This gene encodes one of the mitochondrial translation elongation factors. Its role in the regulation of normal mitochondrial function and in different disease states attributed to mitochondrial dysfunction is not known. -
Synonyms
GFM1;G elongation factor, mitochondrial 1;G translation elongation factor, mitochondrial;elongation factor G, mitochondrial;EFGM;EGF1;GFM;EF-Gmt;mEF-G 1;elongation factor G1;mitochondrial elongation factor G;mitochondrial elongation factor G1
Recombinant Proteins
- Rhesus macaque
- Rat
- Human
- Zebrafish
- Mouse
- Mammalian Cell
- E.coli
- HEK293
- Mammalian cells
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- His
- His&T7
- His&Fc&Avi
- Flag
- Myc&DDK
- GST
Involved Pathway
GFM1 involved in several pathways and played different roles in them. We selected most pathways GFM1 participated on our site, such as Mitochondrial translation,Mitochondrial translation elongation,Organelle biogenesis and maintenance, which may be useful for your reference. Also, other proteins which involved in the same pathway with GFM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Organelle biogenesis and maintenance | MKS1,MRPS35,UNC119B,BBS12,BBS5,IFT122,IFT80,TTC8,PKD1,IFT88 |
| Mitochondrial translation elongation | TUFM,MRPL47,MRPL46,MRPS31,MRPL49,MRPL45,MRPL44,MRPS33,MRPL50,MRPS34 |
| Mitochondrial translation | MRPS33,MRPL49,MTIF3,GFM2,MRPS30,MRPL42,MRPL48,CHCHD1,MRPS27,MRPL52 |
Protein Function
GFM1 has several biochemical functions, for example, GTP binding,GTPase activity,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GFM1 itself. We selected most functions GFM1 had, and list some proteins which have the same functions with GFM1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | USO1,ZMYND10,CD300LH,SEC14L4,NEFL,PNKD,ACOT7,SNX9,FGF19,SRSF2 |
| GTPase activity | GNA13,RAB5B,ARF6,DNM1B,TUBA1C,RAB25A,RAB5C,RAB1BA,RNF112,EEF1A1 |
| translation elongation factor activity | EEF2A.2,EEF1A1L2,TUFM,EEF1A1L1,HBS1L,EEF2B,EEF1A1,EEF1E1,EEF1D,EEF1DA |
| poly(A) RNA binding | NIP7,HNRPLL,SART3,SPTBN1,CCDC55,MBNL2,TRMT6,ZCCHC17,DDX31,RPL6 |
| GTP binding | RAC3,RAB32,GNA13A,RND3B,EHD3,EHD1B,NMUR2,SEPT9,RAB3D,SEPT6 |
Interacting Protein
GFM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GFM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GFM1.
TRIM63;TRIM55;q8clv2_yerpe;SMURF2;MAPK13;SLX4;MAGOHB;Dda1
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