GDI2
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Official Full Name
GDP dissociation inhibitor 2 -
Overview
GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI2 is ubiquitously expressed. The GDI2 gene contains many repetitive elements indicating that it may be prone to inversion/deletion rearrangements. Alternative splicing results in multiple transcript variants encoding distinct isoforms. -
Synonyms
GDI2;GDP dissociation inhibitor 2;rab GDP dissociation inhibitor beta;rab GDP dissociation;RABGDIB;GDI-2;GDIB_HUMAN;Guanosine diphosphate dissociation inhibitor 2;Rab GDI beta;rab GDP-dissociation inhibitor, beta
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Rat
- Chicken
- Mouse
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- Yeast
- In Vitro Cell Free System
- His
- Non
- T7
- DDK
- Myc
- Avi
- Fc
- SUMO
- GST
Involved Pathway
GDI2 involved in several pathways and played different roles in them. We selected most pathways GDI2 participated on our site, such as Rho GTPase cycle,Signal Transduction,Signaling by Rho GTPases, which may be useful for your reference. Also, other proteins which involved in the same pathway with GDI2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signaling by Rho GTPases | ARHGAP36,ARHGAP18,CIT,NCKIPSD,ARAP2,RTKN,ARHGAP29B,ARHGAP9,ROPN1,ARHGAP25 |
| Signal Transduction | ARHGAP22,TAAR1,PROKR1A,PRICKLE1,GAL,ARHGAP44,CHN1,LPAR2B,SKIA,NEDD8L |
| Rho GTPase cycle | ARHGAP11A,ARHGAP44,GDI1,ARHGAP40,ARHGAP19,ARHGAP10,ARHGAP32,RHOT1A,ARHGAP17,ARHGAP25 |
Protein Function
GDI2 has several biochemical functions, for example, GTPase activator activity,Rab GDP-dissociation inhibitor activity,oxidoreductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GDI2 itself. We selected most functions GDI2 had, and list some proteins which have the same functions with GDI2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTPase activator activity | GNAQ,TBC1D10B,ASAP2B,RGS18,TBC1D13,BNIP2,ARFGAP1,ARHGAP26,BCR,ARHGAP6 |
| small GTPase binding | PEX5L,ERRFI1,ABCA1,FGD2,RNF152,FGD1,PEX5,FGD5,FLNA,FGD6 |
| Rab GDP-dissociation inhibitor activity | GDI1 |
| oxidoreductase activity | FAM84B,RTN4IP1,CYP2C19,ERO1LB,C10orf33,TXNRD3,ADOA,CYP8B2,DIO3,AKR1C21 |
| protein binding | PSMD11,CALML3,PRSS21,DNAJC7,PRMT8,LATS1,CLIC3,SPRED2,NEK9,HACE1 |
| poly(A) RNA binding | SRFBP1,SNRPG,MRPS26,RTCA,SUPT6H,PKN2,RBM6,LUZP4,RPUSD3,FNDC3A |
Interacting Protein
GDI2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GDI2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GDI2.
Rab10;Rab5c;RAB4A;SGK1;EIF1B;GH1;Cdk1;VHL;EIF6;ARF6;PAK2;TNFRSF14;RAB24;ACTR6;ATG5;PRKAB1
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References
- Guo, T; Zhang, LQ; et al. Manganese superoxide dismutase is required to maintain osteoclast differentiation and function under static force. SCIENTIFIC REPORTS 5:-(2015).
- Hegglin, A; Mikkat, S; et al. Proteomic Study Points Towards Rho-GDI2-connected Signalling During Skin Graft Revascularization. TISSUE ENGINEERING PART A 20:S125-S125(2014).
