GCNT2
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Official Full Name
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -
Overview
This gene encodes the enzyme responsible for formation of the blood group I antigen. The i and I antigens are distinguished by linear and branched poly-N-acetyllactosaminoglycans, respectively. The encoded protein is the I-branching enzyme, a beta-1,6-N-acetylglucosaminyltransferase responsible for the conversion of fetal i antigen to adult I antigen in erythrocytes during embryonic development. Mutations in this gene have been associated with adult i blood group phenotype. Alternatively spliced transcript variants encoding different isoforms have been described. -
Synonyms
GCNT2;glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group);N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase;bA360O19.2;bA421M1.1;IGNT;Ii blood group;NAGCT1;ULG3;unassigned linkage group 3;Beta 1 6 N acetylglucosaminyltransferase 2;CCAT;GCNT 2;GCNT2C;GCNT5;Glucosaminyl (N acetyl) transferase 2 I branching enzyme (I blood group);Glucosaminyl (N acetyl) transferase 2 I branching enzyme;I beta 1 6 N acetylglucosaminyltransferase;I branching beta 1 6 acetylglucosaminyltransferase;I branching enzyme;II;MGC163396;N acetylglucosaminyltransferase;N acetyllactosaminide beta 1 6 N acetylglucosaminyltransferase;NACGT1;I-branching enzyme;OTTHUMP00000016015;OTTHUMP00000016018;OTTHUMP00000016021;N-acetylglucosaminyltransferase;I beta-1,6-N-acetylglucosaminyltransferase;beta-1,6-N-acetylglucosaminyltransferase 2;I-branching beta-1,6-acetylglucosaminyltransferase;N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase
Recombinant Proteins
- Human
- Mouse
- Mus musculus
- CHO
- HEK293
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- E.coli expression system
- His
- Myc&DDK
- Non
- His&GFP
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GCNT2-01H |
Active Recombinant Human GCNT2 protein, His-tagged
|
CHO | Human | His |
|
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| GCNT2-667H | Recombinant Human GCNT2 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
|
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| GCNT2-89H | Recombinant Human GCNT2, His-tagged | HEK293 | Human | His | 21-402 a.a. |
|
| GCNT2-5979HCL | Recombinant Human GCNT2 293 Cell Lysate | HEK293 | Human | Non |
|
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| GCNT2-10H | Active Recombinant Human GCNT2 Protein (AA 26-400), N-6×His/GFP tagged | HEK293 | Human | His&GFP | AA 26-400 |
|
| Gcnt2-3176M | Recombinant Mouse Gcnt2 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
|
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| GCNT2-4805H | Recombinant Human GCNT2 Protein, GST-tagged | Wheat Germ | Human | GST |
|
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| GCNT2-5186HF | Recombinant Full Length Human GCNT2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 402 amino acids |
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| RFL3098MF | Recombinant Full Length Mouse N-Acetyllactosaminide Beta-1,6-N-Acetylglucosaminyl-Transferase(Gcnt2) Protein, His-Tagged | E.coli expression system | Mus musculus | His | Full L. Full Length (1-401) |
|
Involved Pathway
GCNT2 involved in several pathways and played different roles in them. We selected most pathways GCNT2 participated on our site, such as Glycosphingolipid biosynthesis - lacto and neolacto series,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with GCNT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | HADHB,CYP2C37,SAT2B,ADSSL1,PCYT1BA,SGPL1,CRLS1,ALG10,B3GNT2,PFKL |
| Glycosphingolipid biosynthesis - lacto and neolacto series | FUT6,ST3GAL3B,B3GALT1,B3GNT1,FUT3,FUT5,B3GALT2,B3GNT5B,B3GNT4,GGTA1 |
Protein Function
GCNT2 has several biochemical functions, for example, N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity,N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GCNT2 itself. We selected most functions GCNT2 had, and list some proteins which have the same functions with GCNT2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity | B3GNT1,B3GNT4,B3GNT3,B3GNT2 |
| N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity | GCNT4,GCNT3 |
Interacting Protein
GCNT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GCNT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GCNT2.
Resources
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References
- Nonaka, M; Fukuda, MN; et al. Determination of Carbohydrate Structure Recognized by Prostate-specific F77 Monoclonal Antibody through Expression Analysis of Glycosyltransferase Genes. JOURNAL OF BIOLOGICAL CHEMISTRY 289:16478-16486(2014).
- Henion, TR; Schwarting, GA; et al. N-Linked Polylactosamine Glycan Synthesis Is Regulated by Co-Expression of beta 3GnT2 and GCNT2. JOURNAL OF CELLULAR PHYSIOLOGY 229:471-478(2014).
