GAP43
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Official Full Name
Gap43 growth associated protein 43 -
Overview
GAP43 is a phosphoprotein of the presynaptic membrane involved in synaptic reorganization and neural development. It is present at high levels in neuronal growth cones during development and axonal regeneration. GAP43 is normally produced by neurons during developmental growth and axonal regeneration, but it is also expressed in specific regions of the normal adult nervous system. -
Synonyms
GAP43;growth associated protein 43;neuromodulin;growth-associated protein 43;axonal membrane protein GAP-43;growth accentuating protein 43;calmodulin-binding protein P-57;brain abundant, membrane attached signal protein 2;B-50;Basp2;GAP-43
Recombinant Proteins
- Human
- Rat
- Cynomolgus
- Mouse
- Zebrafish
- HEK293
- Mammalian Cell
- Wheat Germ
- E.coli
- Human Cell
- In Vitro Cell Free System
- E. coli
- HEK293T
- His
- Non
- His&T7
- Myc&DDK
- His&Fc&Avi
- GST
Involved Pathway
GAP43 involved in several pathways and played different roles in them. We selected most pathways GAP43 participated on our site, such as Glial Cell Differentiation,N-cadherin signaling events,Spinal Cord Injury, which may be useful for your reference. Also, other proteins which involved in the same pathway with GAP43 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Spinal Cord Injury | GDNF,RTN4,OMG,TNFSF13B,PTPRZ1,NOX4,MBP,KLK8,RTN4R,AIF1 |
| N-cadherin signaling events | CNR1 |
| Glial Cell Differentiation | PLP1,TPPP,CNP,MBP |
Protein Function
GAP43 has several biochemical functions, for example, calmodulin binding,lysophosphatidic acid binding,phosphatidylinositol phosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GAP43 itself. We selected most functions GAP43 had, and list some proteins which have the same functions with GAP43. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phosphatidylserine binding | SYT4,AXL,CPNE1,OSBPL8,MARK1,PLCD1,OSBPL10,CD300A,SCIN,ANXA13 |
| phosphatidylinositol phosphate binding | RNF34,RPH3A,PLCD1,SNX11,ANKFY1 |
| protein binding | AHNAK,C14orf135,RAB27B,FOXL2,SNRPA,ZNF230,TOM1,SHKBP1,AVPR2,GPANK1 |
| calmodulin binding | CAMK1GB,EPB41B,MYO5C,KCNQ3,DAPK2,MARCKSL1,MYO3A,ADD3,MYLK2,SLC8A1 |
| lysophosphatidic acid binding | LPAR1,VIL1 |
Interacting Protein
GAP43 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GAP43 here. Most of them are supplied by our site. Hope this information will be useful for your research of GAP43.
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References
- Bystrom, S; Ayoglu, B; et al. Affinity Proteomic Profiling of Plasma, Cerebrospinal Fluid, and Brain Tissue within Multiple Sclerosis. JOURNAL OF PROTEOME RESEARCH 13:4607-4619(2014).
- Sanna, MD; Quattrone, A; et al. The RNA-binding protein HuD promotes spinal GAP43 overexpression in antiretroviral-induced neuropathy. EXPERIMENTAL NEUROLOGY 261:343-353(2014).
