G6PC
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Official Full Name
glucose-6-phosphatase, catalytic subunit -
Overview
Glucose-6-phosphatase (G6Pase) is a multi-subunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for G6P, inorganic phosphate, and glucose. This gene (G6PC) is one of the three glucose-6-phosphatase catalytic-subunit-encoding genes in human: G6PC, G6PC2 and G6PC3. Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I (GSD1). This disease, also known as von Gierke disease, is a metabolic disorder characterized by severe hypoglycemia associated with the accumulation of glycogen and fat in the liver and kidneys. -
Synonyms
G6PC;glucose-6-phosphatase, catalytic subunit;G6PT, glucose 6 phosphatase, catalytic (glycogen storage disease type I, von Gierke disease);glucose-6-phosphatase;glycogen storage disease type I;von Gierke disease;GSD1a;GSD1;AW107337;G-6-Pase;G6Pase;G6Pase-alpha;G6PC_HUMAN;G6PT;Glucose-6-phosphatase alpha;MGC163350;MGC93613;RP23-281C18.19;G6PC1
Recombinant Proteins
- Rat
- Human
- Mouse
- Haplochromis xenognathus (Lake Victoria cichlid) (Ptyochromis xenognathus)
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- E.coli
- In Vitro Cell Free System
- Yeast
- Insect Cell
- E.coli expression system
- His
- Non
- Myc&DDK
- His&Fc&Avi
- N-His-SUMO
- GST
- N-His-sumostar
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| G6PC-2435R | Recombinant Rat G6PC Protein | Mammalian Cell | Rat | His |
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| G6PC-27523TH | Recombinant Human G6PC | Wheat Germ | Human | Non | 357 amino acids |
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| G6PC-6129M | Recombinant Mouse G6PC Protein | Mammalian Cell | Mouse | His |
|
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| G6PC-6082HCL | Recombinant Human G6PC 293 Cell Lysate | HEK293 | Human | Non |
|
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| G6PC-01HFL | Recombinant Human G6PC Protein, Full Length, N-His tagged | HEK293 | Human | His | Full L. Full Length |
|
| G6PC1-25HFL | Recombinant Full Length Human G6PC1 Protein, C-Myc/DDK-tagged | HEK293T | Human | Myc&DDK | Full L. |
|
| G6PC-1542H | Recombinant Human G6PC Protein, His-tagged | E.coli | Human | His | Val57-Ala204 |
|
| G6PC-1543H | Recombinant Human G6PC protein, His-tagged | E.coli | Human | His | Asn276~Leu357 |
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| G6PC174HF | Recombinant Full Length Human G6PC Protein | In Vitro Cell Free System | Human | Full L. 357 amino acids |
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| G6PC-2091R | Recombinant Rat G6PC Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| G6PC-2091R-B | Recombinant Rat G6PC Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| G6PC-3416M | Recombinant Mouse G6PC Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| G6PC-3416M-B | Recombinant Mouse G6PC Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| G6PC-4222H | Recombinant Human G6PC protein, His-SUMO-tagged | E.coli | Human | N-His-SUMO | 82-117aa |
|
| G6PC-4613H | Recombinant Human G6PC Protein, GST-tagged | Wheat Germ | Human | GST |
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| G6PC-5122HF | Recombinant Full Length Human G6PC Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 357 amino acids |
|
| G6PC-5754H | Recombinant Human G6PC protein, His-tagged | Yeast | Human | His | 82-117aa |
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| G6PC-5755H | Recombinant Human G6PC protein, His-sumostar-tagged | Yeast | Human | N-His-sumostar | 82-117aa |
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| G6pc-944M | Recombinant Mouse G6pc Protein, His-tagged | Insect Cell | Mouse | His | Met1-Leu357 |
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| RFL23531HF | Recombinant Full Length Haplochromis Xenognathus Glucose-6-Phosphatase(G6Pc) Protein, His-Tagged | E.coli expression system | Haplochromis xenognathus (Lake Victoria cichlid) (Ptyochromis xenognathus) | His | Full L. Full Length (1-277) |
|
Involved Pathway
G6PC involved in several pathways and played different roles in them. We selected most pathways G6PC participated on our site, such as Glycolysis / Gluconeogenesis,Galactose metabolism,Starch and sucrose metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with G6PC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | PIGL,HIBADH,PDHA1A,Atp5g2,MAT2A,ALDH1A1,MAN1B1,ALDH9A1A.1,CKMT1A,CELL |
| Galactose metabolism | G6PC2,GALE,PGM1,G6PCA.2,HK2,HKDC1,LALBA,LCT,AKR1B8,Akr1b3 |
| Insulin signaling pathway | PPP1R3A,FLOT1,BAD,PHKG1A,PRKCI,SH2B2,FASN,INPPL1A,PRKAG2A,PHKA2 |
| PIK-Akt signaling pathway | TCL1B1,LAMB2,COL6A6,YWHAE,COL24A1,ITGB1,THBS1,ITGB3,ITGA3,PRL |
| Carbohydrate digestion and absorption | AMY2A,AKT2,SLC37A4,PLCB2,SLC5A1,HK1,HKDC1,PIK3R2,HK2,PIK3R1 |
| Starch and sucrose metabolism | GANC,UGP2B,UGT2B15,AMY2A5,UGT1A7,HK1,UGT2A1,GBE1,UGT1A1,UGT2A3 |
| AMPK signaling pathway | ADIPOQ,LEPR,AKT1S1,INSR,IRS4,ELAVL1,IGF1R,PPP2CB,CAB39L,CAMKK2 |
| FoxO signaling pathway | PLK2B,AKT2L,INS,IL7R,PIK3CG,PIK3R2,PIK3R3A,HRAS,SMAD4,MAPK11 |
| Adipocytokine signaling pathway | POMC,LEP,PRKAG1,NFKBIE,PRKAB1B,TNF,MAPK9,ACSL4,AKT1,PRKAG2A |
Protein Function
G6PC has several biochemical functions, for example, glucose-6-phosphatase activity,phosphate ion binding,phosphotransferase activity, alcohol group as acceptor. Some of the functions are cooperated with other proteins, some of the functions could acted by G6PC itself. We selected most functions G6PC had, and list some proteins which have the same functions with G6PC. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phosphotransferase activity, alcohol group as acceptor | ADKB,FGGY,FAM20B,PI4KAA,POMK,SGK196,PI4KAP2,GKUP,ADKA,SMG1 |
| glucose-6-phosphatase activity | G6PCA.2,G6PC3,G6PC2,G6PCA.1 |
| phosphate ion binding | RPH3A,ADSS,RELA,OTC,GNG12,SH2B3,ADSSL1,MTHFD2,PNP,SLC34A2 |
Interacting Protein
G6PC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with G6PC here. Most of them are supplied by our site. Hope this information will be useful for your research of G6PC.
CDH16;NSL1;SNX13
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References
- Zhou, YL; Wei, XH; et al. Potassium diformate influences gene expression of GH/IGF-I axis and glucose homeostasis in weaning piglets. LIVESTOCK SCIENCE 172:85-90(2015).
- Zheng, BX; Lin, Q; et al. Three novel mutations of the G6PC gene identified in Chinese patients with glycogen storage disease type Ia. EUROPEAN JOURNAL OF PEDIATRICS 174:59-63(2015).
