FUT1
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Official Full Name
fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) -
Overview
The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the soluble A and B antigen synthesis pathway. This gene is one of two encoding the galactoside 2-L-fucosyltransferase enzyme. Mutations in this gene are a cause of the H-Bombay blood group. -
Synonyms
FUT1;fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group);fucosyltransferase 1 (galactoside 2 alpha L fucosyltransferase) , fucosyltransferase 1 (galactoside 2 alpha L fucosyltransferase, Bombay phenotype included) , H, HSC;g
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Mouse
- Mus musculus
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- Human Cells
- In Vitro Cell Free System
- His
- Non
- Avi
- Fc
- GFP
- DDK
- Myc
- GST
Involved Pathway
FUT1 involved in several pathways and played different roles in them. We selected most pathways FUT1 participated on our site, such as Glycosphingolipid biosynthesis - lacto and neolacto series,Glycosphingolipid biosynthesis - globo series,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with FUT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | NME6,HMBSB,PRIM1,MTMR1,COQ5,NT5C1AA,OGDH,MOCS2,PFKMB,NDUFA6 |
| Glycosphingolipid biosynthesis - lacto and neolacto series | FUT9A,ST3GAL3,GCNT2,B3GNT3,FUT7,B4GALT1,FUT4,FUT5,B4GALT4,B3GNT5 |
| Glycosphingolipid biosynthesis - globo series | FUT9,ST3GAL1,FUT2,GBGT1,ST3GAL2,GLA,B3GALNT1,B3GALT5,GBGT1L4,HEXB |
Protein Function
FUT1 has several biochemical functions, for example, fucosyltransferase activity,galactoside 2-alpha-L-fucosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FUT1 itself. We selected most functions FUT1 had, and list some proteins which have the same functions with FUT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| galactoside 2-alpha-L-fucosyltransferase activity | FUT2 |
| fucosyltransferase activity | FUT4,B3GNT8,DPY19L1,POC1BL,POMGNT2,FT2,POFUT1,GTDC2,FUT2,B3GNT9-PS |
Interacting Protein
FUT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FUT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FUT1.
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References
- Aziz, F; Qiu, Y; et al. The Role of Anti-LeY Antibody in the Downregulation of MAPKs/COX-2 Pathway in Gastric Cancer. CURRENT DRUG TARGETS 15:469-476(2014).
- Nonaka, M; Fukuda, MN; et al. Determination of Carbohydrate Structure Recognized by Prostate-specific F77 Monoclonal Antibody through Expression Analysis of Glycosyltransferase Genes. JOURNAL OF BIOLOGICAL CHEMISTRY 289:16478-16486(2014).
