FLCN
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Official Full Name
folliculin -
Overview
The protein folliculin (FLCN) is encoded by the BHD (Birt-Hogg-Dube) gene that is altered in BHD Syndrome, a disorder characterized by the presence of benign connective tissue tumors known as fibrofolliculomas, renal tumors and lung cysts (1). Clinical si -
Synonyms
FLCN;folliculin;BHD;MGC17998;MGC23445;birt-Hogg-Dube syndrome protein;BHD skin lesion fibrofolliculoma protein;FLCL;FLJ45004;FLJ99377;DKFZp547A118
Recombinant Proteins
- Rhesus macaque
- Rat
- Zebrafish
- Human
- Mouse
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- E.coli
- His
- Non
- His&Fc&Avi
- Myc&DDK
- GST
- His&SUMO
Involved Pathway
FLCN involved in several pathways and played different roles in them. We selected most pathways FLCN participated on our site, such as Renal cell carcinoma, which may be useful for your reference. Also, other proteins which involved in the same pathway with FLCN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Renal cell carcinoma | ETS1,RAPGEF1,PIK3R2,EGLN2,RAP1B,PIK3CB,EP300,MAP2K1,TGFB2,PAK2 |
Protein Function
FLCN has several biochemical functions, for example, guanyl-nucleotide exchange factor activity,protein binding,protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FLCN itself. We selected most functions FLCN had, and list some proteins which have the same functions with FLCN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein complex binding | ATP6V1B1,IST1,ATF1,CALCA,CTSL2,WRN,VHLL,LZTFL1,TAB1,PPP1R9B |
| guanyl-nucleotide exchange factor activity | VAV1,DOCK4,SPATA13,ARHGEF11,PREX1,RASGEF1BA,KNDC1,FAM116B,DOCK7,DOCK1 |
| protein binding | NAPG,H2AFZ,FAAH,PPP1R16B,ALKBH6,SCARA5,COL18A1,DNAJC28,TSC22D4,KPNB1 |
Interacting Protein
FLCN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FLCN here. Most of them are supplied by our site. Hope this information will be useful for your research of FLCN.
ORF;PRKAA2;ALDOB;FBP1;TSTD2;TMEFF1;HEMGN;NANS;CCDC180;GABARAP;GABARAPL1;LAMTOR3
Resources
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References
- Iribe, Y; Kuroda, N; et al. Immunohistochemical characterization of renal tumors in patients with Birt-Hogg-Dube Syndrome. PATHOLOGY INTERNATIONAL 65:126-132(2015).
- Guda, K; Veigl, ML; et al. Novel recurrently mutated genes in African American colon cancers. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112:1149-1154(2015).
