FIGF
-
Official Full Name
C-fos induced growth factor (vascular endothelial growth factor D) -
Overview
VEGF-D is a growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. VEGF-D may function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. The protein binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors. VEGF-D is a homodimer; it is also non-covalent and antiparallel. VEGF-D is highly expressed in lung, heart, small intestine and fetal lung, and at lower levels in skeletal muscle, colon, and pancreas. VEGF-D undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3 and VEGFR-2. It first forms an antiparallel homodimer linked by disulfide bonds before secretion. The fully processed VEGF-D is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions. -
Synonyms
VEGF-D;VEGFD;vascular endothelial growth factor D
Recombinant Proteins
- Human
- Rat
- Mouse
- Zebrafish
- Chicken
- Human Cells
- Sf21 Cells
- E.coli
- Mammalian Cells
- Human
- HEK293
- Rabbit
- E. coli
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- Fc
- Avi
- GST
Involved Pathway
FIGF involved in several pathways and played different roles in them. We selected most pathways FIGF participated on our site, such as Ras signaling pathway,Rap signaling pathway,Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with FIGF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Rap signaling pathway | PARD3,RALGDS,FGF4,FGF1,DOCK4,PLCB3,FGFR2,GRIN1,PDGFC,RAC2 |
| Ras signaling pathway | FGF10,PRKACA,PAK7,FGF13,PDGFRA,SHC4,FOXO4,PLD2,MAP2K2,GNG10 |
| Pathways in cancer | FGFR2,AXIN2,BIRC2,Pdgfa&Pdgfb,PTGER2,MSH6,RAF1,WNT10B,BMP4,STK36 |
| PIK-Akt signaling pathway | Il6ra,LAMB3,LAMA3,TP53,PPP2R2B,ITGA6,ITGB8,NR4A1,INS,EIF4E2 |
| Focal adhesion | MYLK2,ROCK2A,THBS4B,PRKCBA,MYL12.1,PRKCG,PPP1CA,PAK6B,RAPGEF1,VEGFAA |
| Cytokine-cytokine receptor interaction | PF4,Ccl21c,IFNGR1,TNFRSF13B,TGFBR1A,CCL19,TNF,IFNA21,CCL11,PDGFRA |
Protein Function
FIGF has several biochemical functions, for example, chemoattractant activity,growth factor activity,platelet-derived growth factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FIGF itself. We selected most functions FIGF had, and list some proteins which have the same functions with FIGF. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| vascular endothelial growth factor receptor binding | VEGFA,CD2AP |
| platelet-derived growth factor receptor binding | PDGFD,PDGFAB,PDGFRB,VEGFA,ITGB3,Pdgfa&Pdgfb,ITGA5,PDGFB,TYMP,PDGFAA |
| vascular endothelial growth factor receptor 3 binding | VEGFC,VHL |
| protein homodimerization activity | SDCBP2,EIF2AK1,HMOX1,IKZF3,KYNU,GALE,DPYD,BMP7A,ENO3,CRYM |
| growth factor activity | FGF20B,NRTN,LACRT,GPI1,INHBAA,PROK1,CLCF1,HDGFRP3,TGFB1,NOV |
| chemoattractant activity | HMGB1,HGF,CXCL12B,SCG2,VEGFA,SAA4,BMP4,PDGFB,VEGFB,FGF2 |
Interacting Protein
FIGF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FIGF here. Most of them are supplied by our site. Hope this information will be useful for your research of FIGF.
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