FGF20
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Official Full Name
Fgf20 fibroblast growth factor 20 -
Overview
Fibroblast growth factor 21(FGF-21) is a novel protein that has been implicated in the regulation of lipid and glucose metabolism under fasting and ketotic conditions. In murine models, FGF-21 is predominantly expressed in liver, but it also expressed in adipose tissue and pancreatic -cells. FGF-21 stimulates glucose uptake in adipocytes. It also protects animals from diet-induced obesity when overexpressed in transgenic mice and lowers blood glucose and triglyceride levels when administered to diabetic rodents. When administered daily for 6 weeks to diabetic rhesus monkeys, FGF-21 caused a dramatic decline in fasting plasma glucose, fructosamine, triglycerides, insulin, and glucagon. Furthermore, elevated plasma FGF-21 concentrations in humans appear to be related to the presence of hepatic and peripheral insulin resistance. -
Synonyms
FGF20;fibroblast growth factor 20;FGF-20
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- Avi&Fc&His
- His&Myc
Involved Pathway
FGF20 involved in several pathways and played different roles in them. We selected most pathways FGF20 participated on our site, such as MAPK signaling pathway,Ras signaling pathway,Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGF20 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Melanoma | FGF4,PDGFD,PDGFA,FGF12,MAPK3,MAP2K1,HRAS,FGFR1,FGF21,PIK3R5 |
| PIK-Akt signaling pathway | GRB2,CCND3,Fasl,CCND1,ITGA2,LPAR3,IFNA17,PRLR,FASLG,FGF18 |
| Rap signaling pathway | PFN2,HGF,PLCB3,ACTG1,RAC2,MAPK1,FARP2,LPAR2,KIT,PRKD2 |
| MAPK signaling pathway | MAP2K5,SOS1,PPP3CCA,NFKB2,CACNA1SA,FGFR4,HSPA1B,TAOK2,TNF,PPP3R2 |
| Ras signaling pathway | PLA2G3,RASA3,PRKCG,GNB3,BRAP,MAPK10,KSR1,RAP1B,RASA1,FGF21 |
| Regulation of Actin Cytoskeleton | PTK2,RAF1A,FGF12,ITGA7,SCINLB,FGFR1,MYLK4,ITGAV,WASLA,ACTG1 |
| Pathways in cancer | FGF6,FGF22,CCNE1,ROCK2,WNT11,WNT6,NTRK1,WNT3A,APPL1,FOS |
Protein Function
FGF20 has several biochemical functions, for example, fibroblast growth factor receptor binding,growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FGF20 itself. We selected most functions FGF20 had, and list some proteins which have the same functions with FGF20. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| fibroblast growth factor receptor binding | FGF3,FRS2,FGF4,FRS3,FGF2,FGF10,FGF20A,FGF1A,FGF1,FGF22 |
| growth factor activity | BMP3,CSF1B,FGF1B,GDF15,GFER,FGF17,GDF6,IGF3,FGF18B,PSPN |
Interacting Protein
FGF20 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGF20 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGF20.
FGF20 Related Signal Pathway
Resources
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References
- Munnamalai, V; Hayashi, T; et al. Notch Prosensory Effects in the Mammalian Cochlea Are Partially Mediated by Fgf20. JOURNAL OF NEUROSCIENCE 32:12876-12884(2012).
- Hayashi, T; Ray, CA; et al. Fgf20 is required for sensory epithelial specification in the developing cochlea. JOURNAL OF NEUROSCIENCE 28:5991-5999(2008).
