FBL
-
Official Full Name
fibrillarin -
Overview
This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin. -
Synonyms
FBL;fibrillarin;rRNA 2-O-methyltransferase fibrillarin;FIB;FLRN;RNU3IP1;34-kD nucleolar scleroderma antigen;34 kDa nucleolar scleroderma antigen;RNA, U3 small nucleolar interacting protein 1;CG9888 gene product from transcript CG9888-RA;34 kD nucleolar scleroderma antigen;FBRL_HUMAN;FIB1;Nop1p;rRNA 2 O methyltransferase fibrillarin;CG9888-PA;Fib-PA;CG9888;Dmel\CG9888;Fibri;GCR-6;GCR6;pen59C5
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Mouse
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- Mouse
- In Vitro Cell Free System
- His
- GST
- His&T7
- Non
- DDK&Myc
- Flag
- Avi&Fc&His
Involved Pathway
FBL involved in several pathways and played different roles in them. We selected most pathways FBL participated on our site, such as Ribosome biogenesis in eukaryotes, which may be useful for your reference. Also, other proteins which involved in the same pathway with FBL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ribosome biogenesis in eukaryotes | XRN2,SBDS,RPP38,CSNK2A2A,NXF2,REXO2,POP7,XPO1,NAT10,RPP40 |
Protein Function
FBL has several biochemical functions, for example, ATPase binding,RNA binding,TFIID-class transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FBL itself. We selected most functions FBL had, and list some proteins which have the same functions with FBL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| rRNA methyltransferase activity | TRMT10B,PRDM11,DIMT1,RNMTL1B,PRMT8B,METTL21D,METTL23,METTL7B,TRMT10C,RNMTL1A |
| RNA binding | NABP1,LARP6,RPL19,PSMA6,TROVE2,A1CF,SKIV2L,TDRKH,TRIM32,APOBEC2 |
| protein binding | NTRK3,UBXN6,PCDHA4,RPS6KA3,ADRA2A,MZB1,SOCS2,GDAP2,MS4A3,SERPINF1 |
| poly(A) RNA binding | PFN1,SNRPG,HNRNPA2B1,HNRNPH1,RPL36A,LUC7L2,RPS10,CTNNA1,EMG1,FAM98B |
| ATPase binding | NSFL1C,EZR,CHRNA7,WFS1,RALB,ATP6V0A4,NKAIN1,USP25,LCK,ALDOB |
| TFIID-class transcription factor binding | ERCC4,NOP58,ZNHIT6,ERCC1 |
Interacting Protein
FBL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBL here. Most of them are supplied by our site. Hope this information will be useful for your research of FBL.
SMN1;ARRB2;DDX5;LOC100911617;Prmt3;Prmt1;Prmt1;RTCA;RIOK3;CFLAR;CIAO1
Resources
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References
- Shih, TS; Her, I; et al. EMULATING THE HUMAN TIBIOFEMORAL JOINT BY USING A FOUR-BAR LINKAGE, CONDYLAR SHAPES AND SLIP RATIO VARIATION. INTERNATIONAL JOURNAL OF ROBOTICS & AUTOMATION 30:70-78(2015).
- Hisamoto, N; Li, C; et al. The C-elegans HGF/Plasminogen-like Protein SVH-1 Has Protease-Dependent and -Independent Functions. CELL REPORTS 9:1628-1634(2014).
