F11R
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Official Full Name
F11 receptor -
Overview
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5 alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established. -
Synonyms
F11R;F11 receptor;JAM1, junctional adhesion molecule 1;junctional adhesion molecule A;CD321;JAM 1;JAM A;JAMA;JCAM;PAM 1;platelet F11 receptor;platelet adhesion molecule 1;junctional adhesion molecule 1;JAM;KAT;JAM1;PAM-1
Recombinant Proteins
- Mouse
- Human
- Rhesus macaque
- Rat
- Chicken
- Mus musculus
- HEK293
- E.coli
- Mammalian cells
- Mammalian Cell
- Wheat Germ
- Human Cell
- HEK293T
- In Vitro Cell Free System
- E.coli expression system
- Fc
- His
- Non
- hIgG4
- GST
- His&Fc
- His&Fc&Avi
- Myc&DDK
Involved Pathway
F11R involved in several pathways and played different roles in them. We selected most pathways F11R participated on our site, such as Cell adhesion molecules (CAMs),Tight junction,Leukocyte transendothelial migration, which may be useful for your reference. Also, other proteins which involved in the same pathway with F11R were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Epithelial cell signaling in Helicobacter pylori infection | IL-8,MET,NFKB1,ATP6V0D2,IKBKB,ATP6V1B1,ATP6V1E1,ATP6V1B2,CXCR2,PLCG2 |
| Tight junction | CLDN22,PTEN,CLDND,ACTB2,ACTN1,CLDN7B,PTENB,MYH11,OCLNB,MYH6 |
| Leukocyte transendothelial migration | MSN,CLDN8,CLDN15,CLDN4,RAC2,PRKCB,MYL7,MAPK12,PXN,CYBA |
| Cell adhesion molecules (CAMs) | JAM3,NLGN1,Ntng2,SELP,CLDN20,HLA-C,CLDN1,CLDN15,CLDN2,NLGN2B |
Protein Function
F11R has several biochemical functions, for example, PDZ domain binding,protein binding,virus receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by F11R itself. We selected most functions F11R had, and list some proteins which have the same functions with F11R. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | MAP3K1,CTLA4,ZBTB5,ZHX1,GALNT2,PAX8,RNF11,LDB1,KHDC1B,MAPK14 |
| PDZ domain binding | ACCN3,GRIK2,ATP2B3A,Apba1,KIF14,DLG3,SDC2,GRIA1,SLC26A6,SNTA1 |
| virus receptor activity | NPC1,SLAMF1,CCR5,SLC52A2,PVR,ITGB7,ITGB6,CD209,ITGB5,AXL |
Interacting Protein
F11R has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with F11R here. Most of them are supplied by our site. Hope this information will be useful for your research of F11R.
SGTA;PRKCZ;PARD3;BDNF;PEX19;CASK
Resources
Research Area
Other CD AntigenImmunoglobulin Superfamily CAMs
Tight Junction Proteins in Endothelial Cells
Tight Junction Proteins in VSMC
Epithelial Cell Markers and Intracellular Molecules
Tight Junctions
Related Services
Related Products
References
- Babinska, A; Clement, CC; et al. Development of New Antiatherosclerotic and Antithrombotic Drugs Utilizing F11 Receptor (F11R/JAM-A) Peptides. BIOPOLYMERS 102:322-334(2014).
- Schmitt, MMN; Fraemohs, L; et al. Atherogenic mononuclear cell recruitment is facilitated by oxidized lipoprotein-induced endothelial junctional adhesion molecule-A redistribution. ATHEROSCLEROSIS 234:254-264(2014).
