EZH1
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Official Full Name
enhancer of zeste homolog 1 (Drosophila) -
Overview
EZH1 is a component of a noncanonical Polycomb repressive complex-2 (PRC2) that mediates methylation of histone H3 (see MIM 602812) lys27 (H3K27) and functions in the maintenance of embryonic stem cell pluripotency and plasticity (Shen et al., 2008 [PubMed 19026780]).[supplied by OMIM, Mar 2009] -
Synonyms
EZH1;enhancer of zeste homolog 1 (Drosophila);KMT6B;histone-lysine N-methyltransferase EZH1;ENX-2
Recombinant Proteins
- Human
- Rhesus macaque
- Zebrafish
- Mouse
- E.coli
- Mammalian Cell
- Insect Cell
- Wheat Germ
- HEK293
- Mammalian cells
- HEK293T
- In Vitro Cell Free System
- His
- GST
- His&Flag
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
EZH1 involved in several pathways and played different roles in them. We selected most pathways EZH1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with EZH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
EZH1 has several biochemical functions, for example, chromatin binding,histone-lysine N-methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EZH1 itself. We selected most functions EZH1 had, and list some proteins which have the same functions with EZH1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chromatin binding | TAL1,TCF7L1A,CEBPB,HMGN5,SSRP1,HMGB3,APBB1,GLI3,SP110,HMGB3B |
| histone-lysine N-methyltransferase activity | SMYD2B,SETD2,SUV39H1,SETDB1A,SUV39H1A,SETDB1B,SETDB1,SETD1B,EZH2,SETD8B |
Interacting Protein
EZH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EZH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EZH1.
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References
- Nazarullah, A; Martowski, A; et al. Expression Pattern of Polycomb Group Proteins EZH1, EZH2 and Bmi1 in Low Grade Small B-Cell Lymphomas. MODERN PATHOLOGY 28:367A-367A(2015).
- Nazarullah, A; Martowski, A; et al. Expression Pattern of Polycomb Group Proteins EZH1, EZH2 and Bmi1 in Low Grade Small B-Cell Lymphomas. LABORATORY INVESTIGATION 95:367A-367A(2015).
