EIF5A
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Official Full Name
eukaryotic translation initiation factor 5A -
Overview
Eukaryotic translation initiation factor 5A-1 is a protein that in humans is encoded by the EIF5A gene. -
Synonyms
EIF5A;eukaryotic translation initiation factor 5A;eukaryotic translation initiation factor 5A-1;EIF 5A;EIF5A1;MGC99547;MGC104255;eIF 4D;eIF 5A 1;eIF 5A1;eIF-4D;eIF-5A;eIF-5A-1;eIF-5A1;eIF4D;eIF5AI;Eukaryotic initiation factor 5A;Eukaryotic initiation factor 5A isoform 1;Eukaryotic translation initiation factor 5A 1;IF5A1_HUMAN;Rev binding factor;Rev-binding factor;uORF A;uORF
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- Mammalian cells
- HEK293T
- In Vitro Cell Free System
- E. coli
- GST
- His
- Non
- His&Strep
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
EIF5A involved in several pathways and played different roles in them. We selected most pathways EIF5A participated on our site, such as Gamma carboxylation, hypusine formation and arylsulfatase activation,Hypusine synthesis from eIF5A-lysine,Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF5A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hypusine synthesis from eIF5A-lysine | EIF5A2,DHPS,DOHH |
| Gamma carboxylation, hypusine formation and arylsulfatase activation | ARSJ,DPH1,EIF5A2,DPH3,PROCA,ARSE,ARSK,ARSH,ARSD,WDR85 |
| Metabolism of proteins | ARSE,DPH2,ADAMTS8,IGFALS,CTSH,CTSG,SLC25A12,TBCD,MGAT4B,GALNTL5 |
| Post-translational protein modification | RNF2,TRAPPC1,ARSI,EIF5A2,SPON2,SENP1,SPON1,PPP6R1,CNIH3,MUC15 |
| Translation Factors | EIF1,EEF1G,EEF2B,EEF1D,EEF1A2,EIF4EBP2,EEF1B2,PAIP1,EIF2B1 |
Protein Function
EIF5A has several biochemical functions, for example, RNA binding,U6 snRNA binding,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF5A itself. We selected most functions EIF5A had, and list some proteins which have the same functions with EIF5A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| U6 snRNA binding | LSM8,PRPF8,SART3,LSM2,RBM22,DDX39B,PRPF4,LSM7,LSM4 |
| protein binding | NFE2L3,AGO3,BRD9,SSNA1,RGS20,DNAI2,ZNF404,LIMS3L,MARK3,FBP2 |
| poly(A) RNA binding | RRP36,EIF2S1,HIST1H4C,MBNL2,SART3,CCT4,EDF1,CDC5L,ILF3,CHST13 |
| RNA binding | EIF3K,ENDOU2,RPL18A,KIN,EYA1,RBMS2,SKIV2L,EXOSC1,TRIM21,EIF4H |
| protein N-terminus binding | ACTN4,EIF3E,PPP1CC,NTSR1,TARBP2,HAX1,STX5A,YWHAQ,STX1A,PDCD10 |
| translation elongation factor activity | EEFSEC,ABTB1,EEF1B2,EEF1A1,EEF1A2,EFTUD1,EEF1D,EIF5A2,EEF1A1B,EEF1G |
| ribosome binding | PPP1R2P9,CPEB1A,IGHMBP2,EIF2S1,EIF3K,CPEB1B,EFTUD1,ETF1A,CPEB3,EIF5A2 |
Interacting Protein
EIF5A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF5A here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF5A.
MEOX2;CRX;DHPS;REL;KAT2B;Pds5a;Csnk1e;gerLA;XRN2;GABARAP;SOD1;NS
Resources
Research Area
Myogenesis MarkersTranslation Regulation by the Akt Pathway
Skeletal Muscle Markers
p53 Pathway
Related Services
Related Products
References
- Carvajal-Gamez, BI; Quintas-Granados, LI; et al. Translation initiation factor eIF-5A; the hypusine-containing protein, is phosphorylated on serine and tyrosine and O-glycosylated in Trichomonas vaginalis. MICROBIAL PATHOGENESIS 52:177-183(2012).
- Kim, YS; Lee, SS; et al. Immunohistochemical Array for Clear Cell Type Mucoepidermoid Carcinoma. KOREAN JOURNAL OF PATHOLOGY 44:284-294(2010).
