EIF4A2
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Official Full Name
eukaryotic translation initiation factor 4A2 -
Overview
Eukaryotic initiation factor 4A plays an important role in the binding of mRNA to the 43S preinitiation complex when protein synthesis begins. Two highly homologous forms of functional EIF4A genes, Eif4a1 and Eif4a2, have been isolated in mice; yeast cells also possess 2 EIF4A genes, TIF1 and TIF2. The murine Eif4a and yeast TIF genes appear to belong to a DEAD-box gene family, whose members exhibit extensive amino acid similarity and contain the asp-glu-ala-asp (DEAD) sequence. DEAD-box genes have been identified in species ranging from E-coli to humans. Their function appears to be related to transcriptional/translational regulation (referenced from OMIM). -
Synonyms
EIF4A2;eukaryotic translation initiation factor 4A2;DDX2B;EIF4A;EIF4F;BM-010;eIF4A-II;eIF-4A-II;eukaryotic initiation factor 4A-II;ATP-dependent RNA helicase eIF4A-2;eukaryotic translation initiation factor 4A, isoform 2
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Rat
- Cynomolgus
- Chicken
- Mouse
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- Avi
- Fc
- DDK
- Myc
- Flag
Involved Pathway
EIF4A2 involved in several pathways and played different roles in them. We selected most pathways EIF4A2 participated on our site, such as Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S,Antiviral mechanism by IFN-stimulated genes,Cap-dependent Translation Initiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF4A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| GTP hydrolysis and joining of the 60S ribosomal subunit | EIF3K,EIF2S1A,EIF1AXA,RPL35,EIF4B,EIF2S1,FAUB,EIF4A1,EIF2S3,EIF5 |
| Eukaryotic Translation Initiation | EIF2S1,EIF5,EIF2B1,EIF2S1A,EIF2S3,EIF1AX,EIF4H,FAUB,EIF4B,EIF4G1 |
| Deadenylation of mRNA | EIF4E,D1BWG0212E,EIF4B,EIF4A1,C2orf29,TNKS1BP1,PAIP1,EIF4EB,EIF4G1 |
| Deadenylation-dependent mRNA decay | EIF4E,EIF4EB,NT5C3B,EXOSC8,EIF4G1,LSM6,EIF4B,PAIP1,C2orf29,DCP1B |
| Cytokine Signaling in Immune system | SPRED1,MX2,KPNA3,JAK1,NEFLB,SAMHD1,IL17RD,ARIH1,IFI6,DPF1 |
| Cap-dependent Translation Initiation | EIF1AX,EIF4EB,EIF4EBP1,EIF2S1A,EIF4E,EIF4G1,EIF2S3,EIF2B1,EIF5,FAUB |
| Antiviral mechanism by IFN-stimulated genes | NUP35,IFIT11,NUPL2,KPNA3,IFIT8,NUP50,IFIT10,HERC5,KPNA5,EIF4G1 |
| Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | EIF4EBP1,EIF4E,EIF1AX,EIF4A1,EIF4G1,FAUB,EIF4B,EIF4H,EIF1AXA,EIF2S1 |
Protein Function
EIF4A2 has several biochemical functions, for example, ATP binding,ATP-dependent RNA helicase activity,ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF4A2 itself. We selected most functions EIF4A2 had, and list some proteins which have the same functions with EIF4A2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | ENPP1,YSK4,GM7168,NAT10,EPHA4A,ERCC6L2,SCYL2,ERN2,EHD2,KDRL |
| protein binding | CD244,SOX14,SMAD2,GLYAT,FRS2,CD1d1,DNM1,NF1,GOLGA3,CRP |
| ATPase activity | ATAD2B,ABCF3,DNAH6,CARNS1,PEX6,ATP13A3,ABCB1A,CLPX,ABCA6,NSFB |
| helicase activity | HLTF,FANCM,MOV10,SMARCA4,ZRANB3,SMARCA2,MCM9,MOV10B.2,SMARCAD1,SUPV3L1 |
| poly(A) RNA binding | PRAC,PDCD11,DDX10,EXOSC9,C22orf28,PPIA,DCD,RPS17,RPS4Y1,DHX32 |
| translation initiation factor activity | EIF4A1,EIF4EB,EIF2B5,EIF4G2,EIF3HA,EIF5B,EIF3F,EIF2D,EIF3BA,MCTS1 |
| ATP-dependent RNA helicase activity | DHX35,DHX30,SUPV3L1,DDX10,DDX39,DDX28,DDX39AA,G3BP1,TDRD9,DDX6 |
Interacting Protein
EIF4A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF4A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF4A2.
PDCD4;p27958-pro_0000037577;EIF4G1;EIF3H;EIF4G2;DPPA4
EIF4A2 Related Signal Pathway
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References
- Yan, X; Dong, XC; et al. Reference Gene Selection for Quantitative Real-Time PCR Normalization in Reaumuria soongorica. PLOS ONE 9:-(2014).
- Lu, WT; Wilczynska, A; et al. The diverse roles of the eIF4A family: you are the company you keep. BIOCHEMICAL SOCIETY TRANSACTIONS 42:166-172(2014).
