EGR2

  • Official Full Name

    early growth response 2
  • Overview

    The protein encoded by this gene is a transcription factor with three tandem C2H2-type zinc fingers. Defects in this gene are associated with Charcot-Marie-Tooth disease type 1D (CMT1D), Charcot-Marie-Tooth disease type 4E (CMT4E), and with Dejerine-Sottas syndrome (DSS). Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
  • Synonyms

    EGR2;early growth response 2;AT591;CMT1D;CMT4E;KROX20;E3 SUMO-protein ligase EGR2;zinc finger protein Krox-20;early growth response protein 2;KROX-20, Drosophila, homolog (early growth response-2)

Recombinant Proteins

  • Human
  • Rhesus macaque
  • Rat
  • Mouse
  • E.coli
  • Mammalian Cells
  • Wheat Germ
  • HEK293
  • In Vitro Cell Free System
  • GST
  • His
  • Non
  • T7
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
EGR2-12329H Recombinant Human EGR2, GST-tagged E.coli Human GST 149-499a.a.
EGR2-1400R Recombinant Rhesus monkey EGR2 Protein, His-tagged Mammalian Cells Rhesus macaque His
EGR2-2033R Recombinant Rat EGR2 Protein Mammalian Cells Rat His
EGR2-28469TH Recombinant Human EGR2 Wheat Germ Human Non 77 amino acids
Egr2-30M Recombinant Mouse Egr2 protein, His-tagged E.coli Mouse His Gly150~Ser407
EGR2-3123H Recombinant Human EGR2 Protein, GST-tagged Wheat Germ Human GST
EGR2-5053M Recombinant Mouse EGR2 Protein Mammalian Cells Mouse His
EGR2-6976H Recombinant Human EGR2 protein, His & T7-tagged E.coli Human His&T7 Gly147~Cys403
EGR2-777H Recombinant Human EGR2 Protein, His-tagged E.coli Human His
EGR2-6691HCL Recombinant Human EGR2 293 Cell Lysate HEK293 Human Non
EGR2-1225R Recombinant Rhesus Macaque EGR2 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
EGR2-1225R-B Recombinant Rhesus Macaque EGR2 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
EGR2-1690R Recombinant Rat EGR2 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
EGR2-1690R-B Recombinant Rat EGR2 Protein Pre-coupled Magnetic Beads HEK293 Rat
EGR2-2048H Recombinant Human EGR2 Protein (Gly147-Cys403), N-His tagged E.coli Human His Gly147-Cys403
EGR2-2683M Recombinant Mouse EGR2 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
EGR2-2683M-B Recombinant Mouse EGR2 Protein Pre-coupled Magnetic Beads HEK293 Mouse
EGR2-4266HF Recombinant Full Length Human EGR2 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 476 amino acids

    Involved Pathway

    EGR2 involved in several pathways and played different roles in them. We selected most pathways EGR2 participated on our site, such as Adipogenesis,BDNF signaling pathway,Calcineurin-regulated NFAT-dependent transcription in lymphocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with EGR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    BDNF signaling pathway CDKL5,IGF2BP1,KCNN2,CSNK2A1,YBX1,GRIP1,DPYSL2,CSNK2A1P,SYN1,GNB2L1
    Hepatitis B PIK3CG,CCNE2,FAS,TLR2,IRF7,NRAS,PIK3R2,PIK3CB,IFIH1,DDX3X
    Transcriptional regulation of white adipocyte differentiation MED19,EBF1,MED9,MED22,MED29,MED21,MED18,CDK19,NR2F2
    Adipogenesis GATA2,BSCL2,AHR,HMGA1-RS1,CFD,CELF1,CNTFR,PLIN2,BMP1,DVL1
    Calcineurin-regulated NFAT-dependent transcription in lymphocytes CSF2,EGR1,DGKA,IRF4,BATF3,JUNB,EGR4,POU2F1,IKZF1,CDK4
    Developmental Biology FOXD3,SEMA4D,PAQR3B,MED21,CACNG8A,KDR,DLG3,AP2M1,MEF2B,MED6
    IL4-mediated signaling events TFF3,IRF4,MYB,DOK2,RETNLB,IgG3,CCL26,PARP14,MYBL1,NIPAL1
    HTLV-I infection RRAS2,MSX1,XBP1,DVL1,ANAPC7,PIK3CD,FZD10,GM-CSF,Pdgfa&Pdgfb,FZD3

    Protein Function

    EGR2 has several biochemical functions, for example, HMG box domain binding,RNA polymerase II activating transcription factor binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EGR2 itself. We selected most functions EGR2 had, and list some proteins which have the same functions with EGR2. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II activating transcription factor binding PITX2,IFI27,LDB1,CREB1,MAD2L2,BHLHE40,EP300,NEUROD1,LMO2,ZFPM1
    RNA polymerase II core promoter proximal region sequence-specific DNA binding ZNF460,E2F4,NEUROD1,FOXK2,HIST2H3A,ZSCAN21,NFATC4,ELF4,POU1F1,NR1H2
    protein binding CALCOCO1,GTF2H3,WAPAL,SDCBP2,SHISA5,DNAJC5B,SNW1,CTNNA3,TAG-260,NCBP2
    transcription regulatory region DNA binding GABPB1,BRCA1,KCNA3,ZFP335,KLF1,SALL3,ZFP639,TNF,PHB,SALL1A
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding HOXA10,MYBL2,OTX1,TRP63,HNF4A,NFIB,ALS2CR8,MZF1,PHOX2B,KCNA3
    ligase activity RNF20,DTX1,SYVN1,RAD18,UBE2F,BARD1,TRIM33,BTR22,PARK2,UBR2
    HMG box domain binding CEBPA,PRRX1,GATA3,DLX5,HHEX,HOXC4,OLIG2,UTF1,MEOX1,SP1
    transcription factor activity, sequence-specific DNA binding SIM2,HOXB6A,MTA3,TBX16,GLIS2,ETS1,MEOX1,RFX1A,RUNX3,POU4F3
    chromatin binding MSL1,ZEB1,PCNA,UBE2T,HCFC1,NEUROG1,KDM1A,HMGB1,PPARG,DNAJC2

    Interacting Protein

    EGR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EGR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of EGR2.

    NDUFS2;BPGM;ACP5;HCFC1;RPL7L1;RBM15B;HN1L;RIMKLB;MED31;Nab2

    Resources

    References

    • Okamura, T; Sumitomo, S; et al. TGF-beta 3-expressing CD4(+)CD25(-)LAG3(+) regulatory T cells control humoral immune responses. NATURE COMMUNICATIONS 6:-(2015).
    • Pletinckx, K; Vaeth, M; et al. Immature dendritic cells convert anergic nonregulatory T cells into Foxp3(-)IL-10(+) regulatory T cells by engaging CD28 and CTLA-4. EUROPEAN JOURNAL OF IMMUNOLOGY 45:480-491(2015).

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