DLG1
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Official Full Name
discs, large homolog 1 (Drosophila) -
Overview
This gene encodes a multi-domain scaffolding protein that is required for normal development. This protein may have a role in septate junction formation, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene, but the full-length nature of some of the variants is not known. -
Synonyms
DLG1;discs, large homolog 1 (Drosophila);discs, large (Drosophila) homolog 1;disks large homolog 1;discs large homolog 1;dJ1061C18.1.1;DLGH1;hdlg;presynaptic protein SAP97;SAP 97;SAP97;synapse associated protein 97;synapse-associated protein 97;SAP-97;DKFZp761P0818;DKFZp781B0426
Recombinant Proteins
- Rhesus macaque
- Rat
- Human
- Mouse
- Zebrafish
- Mammalian Cells
- Wheat Germ
- HEK293
- E.coli
- His
- GST
- DDK
- Myc
- Avi
- Fc
Involved Pathway
DLG1 involved in several pathways and played different roles in them. We selected most pathways DLG1 participated on our site, such as Hippo signaling pathway,T cell receptor signaling pathway,HTLV-I infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with DLG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hippo signaling pathway | FZD7,ID1,BMP8B,WNT2B,LATS2,BBC3,GDF6,SOX2,YWHAB,YWHAH |
| Viral carcinogenesis | HIST1H4K,TP53,YWHAB,GTF2E2,BAD,EIF2AK2,HLA-E,HIST1H4I,YWHAG,TTC6 |
| HTLV-I infection | RELB,IL15RA,ANAPC11,PDGFA,POLE4,GM-CSF,TBPL2,IL2RB,BCL2L1,VDAC2 |
| T cell receptor signaling pathway | MAP2K1,ICOS,PAK3,GSK3B,MAP3K14,VAV1,CBLC,NFKBIB,PPP3R2,EVLB |
Protein Function
DLG1 has several biochemical functions, for example, L27 domain binding,PDZ domain binding,guanylate kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DLG1 itself. We selected most functions DLG1 had, and list some proteins which have the same functions with DLG1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phosphatase binding | PPP1R37,PPP1R35,CSRNP2,CHCHD3,SMAD2,MAST2,CNST,DLG3,DZIP3,CRY1 |
| guanylate kinase activity | DLG3,MPP1,GUK1B,MPP2,TJP2,DLG4,DLG2,GUK1,MPP3,DLG1L |
| potassium channel regulator activity | YWHAE,KCNIP4,KCNIP3,KCNE2,PIAS3,KCNIP2,KCNS3,KCNE1,KCNAB1,KCNMB2 |
| ionotropic glutamate receptor binding | CANX,DLG3,DLG2,SHANK2,FLOT2,DLG4B,NETO1,FUS,SHANK3,RAB4A |
| protein kinase binding | STAT3,THY1,KIF20A,RAB8A,HDAC7,TRAP1,EMP2,APC,RPS3,TELO2 |
| L27 domain binding | LIN7C,LIN7A,LIN7B |
| PDZ domain binding | CLCN3,ADRB1,ATP2B3A,GRID2,MAP2K2,GRIK2,Apba1,LPAR2,DOCK4,PLEKHA1 |
| mitogen-activated protein kinase kinase binding | BRAF,IGBP1,RAF1,TRIB2,TAOK2,ARRB1,PIN1,KSR1,TRIB1,TRIB3 |
| kinase binding | WWC2,WWC1,CAB39,EMP2,SRC,RB1,CDC37,TNFAIP3,PER3,SGOL1 |
Interacting Protein
DLG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DLG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DLG1.
Lrfn2;Nrcam;Grin2b;E6;Dlg4;Scn7a;Fzd1;Lrfn1;Fzd4
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References
- Hawkins, ED; Oliaro, J; et al. Regulation of asymmetric cell division and polarity by Scribble is not required for humoral immunity. NATURE COMMUNICATIONS 4:-(2013).
- Aoyagi, T; Takahashi, M; et al. The PDZ domain binding motif (PBM) of human T-cell leukemia virus type 1 Tax can be substituted by heterologous PBMs from viral oncoproteins during T-cell transformation. VIRUS GENES 40:193-199(2010).
