DLD
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Official Full Name
Lipoamide Dehydrogenase -
Overview
Lipoamide dehydrogenase or dihydrolipoamide dehydrogenase (DLD) is a component of the glycine cleavage system as well as of the alpha ketoacid dehydrogenase complexes. It is a homodimer. It belongs to the class I pyridine nucleotide disulfide oxidoreductase family. Defects in DLD are a cause of congenital infantile lactic acidosis. Moreover, defects in DLD are the cause of DLD deficiency; which results in extensive metabolic disturbances, including lactic acidemia, Krebs cycle dysfunction, and impaired branched amino acid degradation. DLD deficiency also causes neurological degeneration due to the sensitivity of the central nervous system to defects in oxidative metabolism. -
Synonyms
Lipoamide Dehydrogenase;Diaphorase;Dihydrolipoamide dehydrogenase;Dihydrolipoyl dehydrogenase;DLD;Dihydrolipoyl dehydrogenase mitochondrial;DLDH;E3;E3 component of pyruvate dehydrogenase;E3 component of pyruvate dehydrogenase complex 2 oxo glutarate complex branched chain keto acid dehydrogenase complex;GCSL;Glycine cleavage system L protein;Glycine cleavage system protein L;LAD;Lipoamide reductase;Lipoyl dehydrogenase;PHE 3;PHE3;EC=1.8.1.4;DTD;DTD HUMAN;DT DIAPHORASE;DT DIAPHORASE HUMAN;EC 1.8.1.4 TYPE III;EC 1.8.1.4;EC 1.6.99;EC: 1.6.99;EC 1.6.99.2;IUB: 1.6.99.1;QUINONE REDUCTASE;QUINONE REDUCTASE HUMAN;Diaphorase Clostridium kluyveri;DT Diaphorase from rat;DTD, NQO1, Quinone reductase
Recombinant Proteins
- Human
- Rat
- Chicken
- Mouse
- Zebrafish
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- T7
- Non
- Twin Strep
- Flag
- Avi
- Fc
- DDK
- Myc
Involved Pathway
DLD involved in several pathways and played different roles in them. We selected most pathways DLD participated on our site, such as 2-oxobutanoate degradation,2-oxobutanoate degradation I,2-oxoglutarate decarboxylation to succinyl-CoA, which may be useful for your reference. Also, other proteins which involved in the same pathway with DLD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Carbon metabolism | SUCLG2,SDHD,MDH1,HADHA,IDH1,PDHB,IDH3G,ECHS1,RPE,ACO2 |
| 2-oxobutanoate degradation I | DBT |
| Branched-chain amino acid catabolism | HIBADHA,BCKDK,IVD,ALDH9A1A.2,HIBADH,DBT,PPM1K |
| 2-oxobutanoate degradation | DBT |
| 2-oxoglutarate decarboxylation to succinyl-CoA | DLST |
| 2-oxoisovalerate decarboxylation to isobutanoyl-CoA | DBT |
| Citrate cycle (TCA cycle) | OGDHL,IDH3A,DLAT,IDH1,SDHD,IDH3B,MDH1AA,OGDHA,PDHA2,SUCLG2 |
| Biosynthesis of antibiotics | LDHAL6A,CMBL,AKR1A1,EHHADH,DAO1,AMDHD2,ADH5,ADSL,AGXT,NME6 |
Protein Function
DLD has several biochemical functions, for example, NAD binding,dihydrolipoyl dehydrogenase activity,flavin adenine dinucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DLD itself. We selected most functions DLD had, and list some proteins which have the same functions with DLD. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| flavin adenine dinucleotide binding | ACADSB,AOX3L1,AOX3,D2HGDH,ACOX2,CRY-DASH,CYB5R3,GCDHA,ACADS,GSR |
| contributes_to pyruvate dehydrogenase (NAD+) activity | DLAT,PDHB,PDHX |
| NAD binding | AOX4,HADHA,GPD1C,ADH1,HSD11B2,GPD1A,LDHA,AOX1,HSD17B10,ME3 |
| dihydrolipoyl dehydrogenase activity | DLDH |
Interacting Protein
DLD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DLD here. Most of them are supplied by our site. Hope this information will be useful for your research of DLD.
PDHX;ssdna_da;FN1;ATF2;STAT5B;GRB2;ICT1;ESR2;GABARAPL1;MAP1LC3A;HDAC6;SIRT4;Hdac6
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References
- Pauciullo, A; Kupper, J; et al. Wingless-type MMTV integration site family member 2 (WNT2) gene is associated with resistance to MAP in faecal culture and antibody response in Holstein cattle. ANIMAL GENETICS 46:122-132(2015).
- Yoneyama, K; Kojima, S; et al. Proteomic Identification of Autoantibodies in Sera from Patients with Ovarian Cancer as Possible Diagnostic Biomarkers. ANTICANCER RESEARCH 35:881-889(2015).
