DGKE
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Official Full Name
diacylglycerol kinase, epsilon 64kDa -
Overview
Diacylglycerol kinases are thought to be involved mainly in the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction.When expressed in mammalian cells, DGK-epsilon shows specificity for arachidonyl-containing diacylglycerol. DGK-epsilon is expressed predominantly in testis. -
Synonyms
DGKE;diacylglycerol kinase, epsilon 64kDa;diacylglycerol kinase, epsilon (64kD);diacylglycerol kinase epsilon;DAGK6;DGK;DGK-epsilon;DAG kinase epsilon;diglyceride kinase epsilon;DAGK5
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Mus musculus
- Wheat Germ
- Mammalian Cells
- E.coli
- HEK293
- In Vitro Cell Free System
- Non
- GST
- His
- Avi
- Fc
- Myc
- SUMO
- DDK
Involved Pathway
DGKE involved in several pathways and played different roles in them. We selected most pathways DGKE participated on our site, such as Glycerolipid metabolism,Glycerophospholipid metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with DGKE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycerolipid metabolism | AKR1A1,PPAP2D,GPAT2,DGKG,PPAP2CB,AKR1A1B,PNPLA3,LCLAT1,MOGAT1,MBOAT1 |
| Phosphatidylinositol signaling system | MTMR7A,PIK3R3A,PIK3C2B,IP6K1,IMPA1,IP6K2,ITPR3,PIP5K1B,PRKCBB,IP6K3 |
| Glycerophospholipid metabolism | PGS1,GPCPD1,PLD2,ACHE,PLA2G6,AGPAT9,LPIN2,PLA2G15,PPAP2C,CHKB |
| Phospholipase D signaling pathway | INS1,DGKZ,MRAS,GRM6,GRM4,RALB,Pdgfa&Pdgfb,AVPR2,PIK3R5,PDGFRA |
| Choline metabolism in cancer | PDPK1,SLC22A3,AKT2,PIK3CA,SLC44A1,DGKB,CHKB,PDGFA,MAP2K2,EGF |
| Metabolic pathways | CYP2C37,SEPHS1,DNMT3,PLCB2,HMGCLL1,HSD3B6,POLR2H,CDS2,ALOX5A,PMM2 |
Protein Function
DGKE has several biochemical functions, for example, ATP binding,diacylglycerol kinase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DGKE itself. We selected most functions DGKE had, and list some proteins which have the same functions with DGKE. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| diacylglycerol kinase activity | DGKA,DGKB,DGKG,DGKD,DGKAA,DGKQ,TAE1,DGKZ,AGK |
| metal ion binding | ZFP775,ZFP551,ZNF354A,ZNF691,ARAF,ACVR2AA,ZBTB46,ZNF292A,GM12824,ROR2 |
| ATP binding | ACSM2,MAP3K8,ATP6V1BA,HSP104,MYH1B,PIK3CA,FLJ11011L,MSH3,NAT10,PCCA |
Interacting Protein
DGKE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DGKE here. Most of them are supplied by our site. Hope this information will be useful for your research of DGKE.
PDHA1;PAICS;SET;NUF2;NUDC;MRPL44;ARRB2;ARRB1
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