DERL3

  • Official Full Name

    Der1-like domain family, member 3

  • Overview

    The protein encoded by this gene belongs to the derlin family, and resides in the endoplasmic reticulum (ER). Proteins that are unfolded or misfolded in the ER must be refolded or degraded to maintain the homeostasis of the ER. This protein appears to be involved in the degradation of misfolded glycoproteins in the ER. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

  • Synonyms

    DERL3;Der1-like domain family, member 3;C22orf14, chromosome 22 open reading frame 14;derlin-3;derlin 3;FLJ43842;IZP6;MGC71803;C22orf14;Degradation in endoplasmic reticulum protein 3;DER 3;Der1 like domain family member 3;Der1 like protein 3;Der1-like protein 3;DER3;DERL 3;DERL3_HUMAN;Derlin 3 protein;Derlin3;DERtrin 3;DERtrin-3;DERtrin3;IZP 6;LLN 2;LLN2

Recombinant Proteins

  • Zebrafish
  • Human
  • Chicken
  • Mus musculus
  • Bovine
  • Mammalian Cell
  • Wheat Germ
  • HEK293
  • In Vitro Cell Free System
  • E.coli expression system
  • His
  • GST
  • Non
Cat.# Product name Source (Host) Species Tag Protein Length Price
DERL3-11146Z Recombinant Zebrafish DERL3 Mammalian Cell Zebrafish His
DERL3-2548H Recombinant Human DERL3 Protein, GST-tagged Wheat Germ Human GST
DERL3-4652C Recombinant Chicken DERL3 Mammalian Cell Chicken His
DERL3-224HCL Recombinant Human DERL3 lysate HEK293 Human Non
DERL3-2475HF Recombinant Full Length Human DERL3 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 205 amino acids
RFL25269MF Recombinant Full Length Mouse Derlin-3(Derl3) Protein, His-Tagged E.coli expression system Mus musculus His Full L. Full Length (1-228)
RFL25602BF Recombinant Full Length Bovine Derlin-3(Derl3) Protein, His-Tagged E.coli expression system Bovine His Full L. Full Length (1-231)
RFL7736HF Recombinant Full Length Human Derlin-3(Derl3) Protein, His-Tagged E.coli expression system Human His Full L. Full Length (1-235)

    Involved Pathway

    DERL3 involved in several pathways and played different roles in them. We selected most pathways DERL3 participated on our site, such as Apoptosis,Apoptosis Modulation by HSP70,Ceramide signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with DERL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ceramide signaling pathway CRADD,PAWR,CTSD,EGF
    Apoptosis Modulation by HSP70 CASP2
    Apoptosis OCLN,HIST1H1E,IL3,CASP10,GZMC,BADB,BAD,CASP6L2,IRF1B,ATM

    Protein Function

    DERL3 has several biochemical functions, for example, DNA binding,FAD binding,NAD(P)H oxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DERL3 itself. We selected most functions DERL3 had, and list some proteins which have the same functions with DERL3. You can find most of the proteins on our site.

    Function Related Protein
    oxidoreductase activity, acting on NAD(P)H DECR1,WDR93,MIOX,NDUFS8A,ECSIT,NDUFS8B,AIFM1
    DNA binding ZNF596,TFAP4,ALX4B,DMRTA2,BARX2,DTD1,FOXE3,NANOG,UBN2A,Arid4b
    electron carrier activity NDUFV2,SDHB,ACADM,MAOB,XDH,SH3BGRL3,CYBA,NOX4,NDUFS3,AKR7A3
    FAD binding KMO,MICAL1,DAO,MICAL2,DAO.1,MTRR,DAO.2,DAO.3,DDO,MICAL2B
    protein dimerization activity ID2,ATOH8,OLIG4,SOHLH2,USF1L,POLR2J3,FIGLA,RIMKLB,ARNTL1A,HIF3A
    protein binding FYTTD1,SRRT,NEURL1B,PPIA,TNFRSF1A,PIN4,CAMSAP1L1,S100A6,ZNF230,IRS1
    NAD(P)H oxidase activity KMO,NOX4,AIFM1,DUOX2,CYB5R4

    Interacting Protein

    DERL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DERL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of DERL3.

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