DERL1
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Official Full Name
Der1-like domain family, member 1 -
Overview
Derlin-1 also known as degradation in endoplasmic reticulum protein 1 is a protein that in humans is encoded by the DERL1 gene . It is a member of the rhomboid-like clan of polytopic membrane proteins. -
Synonyms
DERL1;Der1-like domain family, member 1;derlin-1;DER 1;DER1;derlin 1;FLJ13784;MGC3067;PRO2577;DERtrin-1;der1-like protein 1;degradation in endoplasmic reticulum protein 1;DER-1;FLJ42092
Recombinant Proteins
- Rhesus macaque
- Zebrafish
- Chicken
- Human
- Mouse
- Bovine
- Dictyostelium Discoideum
- Mus musculus
- Pongo Abelii
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- E.coli
- His
- GST
- Non
- Avi
- Fc
Involved Pathway
DERL1 involved in several pathways and played different roles in them. We selected most pathways DERL1 participated on our site, such as Protein processing in endoplasmic reticulum,Amyotrophic lateral sclerosis (ALS), which may be useful for your reference. Also, other proteins which involved in the same pathway with DERL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Protein processing in endoplasmic reticulum | EIF2AK2,SEC61AL2,UBE2D1A,ERP29,UGGT2,HSP90AA1.2,BAXA,PPP1R15A,BAX,NPLOC4 |
| Amyotrophic lateral sclerosis (ALS) | MAPK14,GRIA2,TNF,CCS,PPP3CA,TNFRSF1B,TNFRSF1A,MAP3K5,RAC1,BCL2 |
Protein Function
DERL1 has several biochemical functions, for example, ATPase binding,MHC class I protein binding,protease binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DERL1 itself. We selected most functions DERL1 had, and list some proteins which have the same functions with DERL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin-specific protease binding | MARCH6,AMFR,PARK2,CHMP3,BAG6,SYVN1,VCP,RAD23A,SELS,PARK7 |
| protease binding | ADAM8A,TRIP4,FURIN,TP53,A2M,SELL,SERPINF2,ADRM1,SERPINB13,Serpina1b |
| protein binding | CCR1,BCOR,LRRC4B,HNRNPA1,DNM1L,CHEK2,CDAN1,USH1C,SLC7A11,UTP23 |
| ubiquitin protein ligase binding | UBE2L3,UBE2T,KCNH2,TUBB,CXCR4,CUL3,ANAPC2,GSK3B,PRKACB,MAGEC2 |
| ATPase binding | PKD2,NUFIP1,GRIN2A,ZNHIT6,RAB4A,LCK,ATP1B1,GABARAPL2,SVIP,FXYD1 |
| receptor activity | NPC1,VMN1R40,VMN1R49,EDAR,GFRA4A,TACSTD2,CLEC4E,RTN4RL1,NLGN2,KLRB1F |
| MHC class I protein binding | LILRB2,CD244,CD8B,BCAP31,ATP5A1,TUBB4B,TAP1,CD8A,VCP,TAPBP |
Interacting Protein
DERL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DERL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DERL1.
TCF25;HM13;CFTR;BCAP31;VIMP;XBP1;ALB;US11;VCP
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