Dcc

  • Official Full Name

    deleted in colorectal carcinoma

  • Overview

    Invasive, metastatic colon cancer arises from pre-existing adenomas in both familial and sporadic cases and is characterized by the presence of multiple chromosomal alterations. In the progression from intramucosal carcinoma to invasive carcinoma, allelic loss on the long arm of chromosome 18 is frequently observed. Recently, a gene on 18q21.3 termed DCC, for deleted in colorectal carcinoma, has been isolated and shown to be deleted or mutated in both sporadic and inherited colon carcinoma whereas normal colonic tissue retained and expressed the gene. Furthermore, loss of DCC expression appears to accompany progression of adenomas to metastatic carcinoma. The inactivation of DCC suggests that it is a tumor suppressor gene. A functional role for DCC as a tumor suppressor gene is indicated by experiments demonstrating that introduction of a normal chromosome 18 into the human colon tumor cell lines COKFu or SW480.7 lacking DCC suppresses tumorigenicity. Analysis of the amino acid sequence deduced from cDNA clones indicates that DCC is a transmembrane glycoprotein consisting of 1447 amino acids with an extracellular domain having extensive similarity to neural cell adhesion molecules (NCAM), a single transmembrane segment, and a unique cytoplasmic domain. The high degree of similarity to NCAMs suggests that DCC is involved in cell-cell interactions essential to the differentiated state of the colonic epithelium. DCC expression has been observed in all tissues examined except liver with the highest level of expression in brain tissue. Alterations in DCC expression have also been observed in pancreatic adenocarcinoma and esophogeal carcinoma. However, DCC mRNA is expressed at very low levels, requiring reverse transcription followed by PCR amplification for unambiguous detection.

  • Synonyms

    DCC;deleted in colorectal carcinoma;netrin receptor DCC;IGDCC1;immunoglobulin superfamily;DCC subclass;member 1;colorectal tumor suppressor;colorectal cancer suppressor;tumor suppressor protein DCC;deleted in colorectal cancer protein;immunoglobulin superfamily DCC subclass member 1;immunoglobulin superfamily, DCC subclass, member 1;CRC18;CRCR1

Recombinant Proteins

  • Mouse
  • Rat
  • Human
  • Zebrafish
  • Sf21 Cells
  • Mammalian Cells
  • E.coli
  • HEK293
  • Non
  • His
  • GST
  • DDK&Myc
  • Avi&Fc&His
  • Fc

    Involved Pathway

    Dcc involved in several pathways and played different roles in them. We selected most pathways Dcc participated on our site, such as Apoptosis,Axon guidance,Caspase activation via extrinsic apoptotic signalig pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Dcc were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    DSCAM interactions DSCAM,DSCAMA,DSCAML1
    Apoptosis BMX,IRF6,HELLS,PRKACBA,RELA,CTNNB2,HIST1H1D,TNFRSF10C,NGF,IRF2
    Caspase activation via extrinsic apoptotic signalig pathway DAPK1,DAPK3,CASP8L1,RNF8,TICAM1
    Developmental Biology ARPC5,SCN2B,SEMA4D,ANK2B,MED19,RND1L,NADL1.1,SDCBP,AP2A2,ADAM23
    Axon guidance AP2M1,SPNA1,Plxna2,ARPC2,CDK5R1B,ARHGEF28,SCN2B,COL4A3,KALRN,NRG3
    Colorectal cancer SMAD3,SMAD4,TGFBR2,PIK3CG,TGFB1,MAP2K1,MSH3,GSK3B,PIK3R3,PIK3CB
    Cell-Cell communication PLECA,CTNND1,CDH8,CDH9,CLDN7,CADM2,FERMT2,DSCAMA,KIRREL,SKAP2
    DCC mediated attractive signaling TRIO,NTN1A,NTN1B,DOCK1

    Protein Function

    Dcc has several biochemical functions, for example, protein binding,transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Dcc itself. We selected most functions Dcc had, and list some proteins which have the same functions with Dcc. You can find most of the proteins on our site.

    Function Related Protein
    transmembrane signaling receptor activity EVI2A,CD27,GPR113,BCAM,OR115-6,CD247,NRXN3,LGR6,THBD,FCGR2C
    protein binding BEND5,CD226,SOX-2,ZNHIT6,SPSB2,XIRP2,CXCR4,LRRFIP2,SMCR7,TWIST2

    Interacting Protein

    Dcc has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Dcc here. Most of them are supplied by our site. Hope this information will be useful for your research of Dcc.

    Resources

    Research Area

    Netrins and Receptors
    Repulsive Guidance Molecules and Receptors

    References

    • Guzvic, M; Braun, B; et al. Combined Genome and Transcriptome Analysis of Single Disseminated Cancer Cells from Bone Marrow of Prostate Cancer Patients Reveals Unexpected Transcriptomes. CANCER RESEARCH 74:7383-7394(2014).
    • Lee, SJ; Jung, YH; et al. Netrin-1 Induces MMP-12-Dependent E-Cadherin Degradation Via the Distinct Activation of PKC alpha and FAK/Fyn in Promoting Mesenchymal Stem Cell Motility. STEM CELLS AND DEVELOPMENT 23:1870-1882(2014).

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