DAAM1
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Official Full Name
dishevelled associated activator of morphogenesis 1 -
Overview
Functions of the cell cortex, including motility, adhesion, and cytokinesis, are mediated by the reorganization of the actin cytoskeleton and recent evidence suggests a role for the Formin homology (FH) proteins in these processes. The protein encoded by this gene contains FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. Wnt/Fz signaling activates the small GTPase Rho, a key regulator of cytoskeleton architecture, to control cell polarity and movement during development. Activation requires Dvl-Rho complex formation, an assembly mediated by this gene product, which is thought to function as a scaffolding protein. Evidence of alternative splicing has been observed for this gene but the full-length nature of these variants has not been determined. -
Synonyms
DAAM1;dishevelled associated activator of morphogenesis 1;disheveled-associated activator of morphogenesis 1;KIAA0666;FLJ41657
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- Mouse
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- GST
- His
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
DAAM1 involved in several pathways and played different roles in them. We selected most pathways DAAM1 participated on our site, such as Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with DAAM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Wnt signaling pathway | RAC1A,PRKCG,TLE3A,FZD3,WNT2BA,ROCK2,CCND2,SMAD4,NFATC2,PPP3R1 |
Protein Function
DAAM1 has several biochemical functions, for example, Rho GTPase binding,actin binding,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DAAM1 itself. We selected most functions DAAM1 had, and list some proteins which have the same functions with DAAM1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Rho GTPase binding | RHOH,DIAPH1,DAAM1B,KIF3B,FMNL2,CSDA,PARD6A,ROCK2,ANTXR2A,DOCK10 |
| protein binding | RARS,CSDE1,UQCRC2,LSM4,GRIP1,DKK1,CLINT1,RC3H2,LRCH4,ZSCAN21 |
| identical protein binding | USP4,GLE1,ETNPPL,UHRF1,SMAD6,C,ESR1,HSP90AA1,FXR2,DCTPP1 |
| actin binding | SYN1,EPB41L2,TMSB,MYHZ1.1,MYBPC2,TWF1B,CFL1,ACTN4,ARPC1A,WASF2 |
Interacting Protein
DAAM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DAAM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DAAM1.
RHOA;SRC;TRIP10;FNBP1L;DVL1;RHOD;RHOC;RHOB;a5j090_xenla
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