CYTH3
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Official Full Name
cytohesin 3 -
Overview
This gene encodes a member of the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. PSCD family members have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This encoded protein is involved in the control of Golgi structure and function, and it may have a physiological role in regulating ADP-ribosylation factor protein 6 (ARF) functions, in addition to acting on ARF1. -
Synonyms
CYTH3;cytohesin 3;pleckstrin homology, Sec7 and coiled coil domains 3 , PSCD3;cytohesin-3;ARNO3;GRP1;ARF nucleotide-binding site opener 3;ARNO3 protein;OTTHUMP00000115876;general receptor of phosphoinositides 1;pleckstrin homology, Sec7 and coiled-coil domains 3;PH, SEC7 and coiled-coil domain-containing protein 3;PSCD3
Recombinant Proteins
- Human
- Mouse
- E.coli
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CYTH3-11803H | Recombinant Human CYTH3, GST-tagged | E.coli | Human | GST | C-term-179a.a. | |
| CYTH3-165H | Recombinant Human CYTH3, His-tagged | E.coli | Human | His | 1-399aa |
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| CYTH3-2305H | Recombinant Human CYTH3 Protein, GST-tagged | Wheat Germ | Human | GST |
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| CYTH3-1425HCL | Recombinant Human CYTH3 cell lysate | Human | Non |
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| CYTH3-1159H | Recombinant Human CYTH3 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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| Cyth3-2430M | Recombinant Mouse Cyth3 Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| CYTH3-2501HF | Recombinant Full Length Human CYTH3 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 179 amino acids |
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| CYTH3-3400H | Recombinant Human CYTH3 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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Involved Pathway
CYTH3 involved in several pathways and played different roles in them. We selected most pathways CYTH3 participated on our site, such as Phospholipase D signaling pathway,Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYTH3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocytosis | RUFY1,SRC,RAB11FIP5,NTRK1,SNX32,EHD4,CSF1RA,HSP70L,LDLRAP1B,CHMP2BB |
| Phospholipase D signaling pathway | MTOR,PLCB4,PPAP2C,DGKZ,SHC3,PDGFRA,FCER1A,GAB1,RALB,MS4A2 |
Protein Function
CYTH3 has several biochemical functions, for example, ARF guanyl-nucleotide exchange factor activity,phosphatidylinositol-3,4,5-trisphosphate binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYTH3 itself. We selected most functions CYTH3 had, and list some proteins which have the same functions with CYTH3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | FBXW5,KCP,TALDO1,NGLY1,KAT2A,KARS,C14orf93,PDGFC,CC10,CDKN1A |
| ARF guanyl-nucleotide exchange factor activity | ARFGEF2,IQSEC1,CYTH4B,FBXO8,CYTH1A,PSD4,PSD2,MON2,CYTH1B,GBF1 |
| phosphatidylinositol-3,4,5-trisphosphate binding | COMMD1,ANXA8,DAPP1,RAG2,ARAP1,D6WSU116E,ZFYVE16,FAM21C,MYO1G,OGT |
Interacting Protein
CYTH3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYTH3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYTH3.
CNKSR1;SYCE1;CCDC120;CALCOCO1
Resources
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References
- El Azreq, MA; Bourgoin, SG; et al. Cytohesin-1 regulates human blood neutrophil adhesion to endothelial cells through beta 2 integrin activation. MOLECULAR IMMUNOLOGY 48:1408-1416(2011).
- Sendide, K; Reiner, NE; et al. Cross-talk between CD14 and complement receptor 3 promotes phagocytosis of mycobacteria: Regulation by phosphatidylinositol 3-kinase and cytohesin-1. JOURNAL OF IMMUNOLOGY 174:4210-4219(2005).
