CYP3A4
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Official Full Name
cytochrome P450, family 3, subfamily A, polypeptide 4 -
Overview
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified. -
Synonyms
CYP3A4;cytochrome P450, family 3, subfamily A, polypeptide 4;HLP;CP33;CP34;CYP3A;NF-25;CYP3A3;P450C3;CYPIIIA3;CYPIIIA4;P450PCN1;MGC126680;cytochrome P450 3A4;OTTHUMP00000210308;cytochrome P450 3A3;cytochrome P450 HLp;cytochrome P450-PCN1;cytochrome P450 NF-25;quinine 3-monooxygenase;albendazole monooxygenase;P450-III, steroid inducible;glucocorticoid-inducible P450;taurochenodeoxycholate 6-alpha-hydroxylase;cytochrome P450, subfamily IIIA, polypeptide 3;cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4
Recombinant Proteins
- Human
- Rhesus macaque
- Cynomolgus
- E.coli
- S.cerevisiae
- HEK293
- Mammalian Cell
- Wheat Germ
- P.pastoris
- Insect Cell
- In Vitro Cell Free System
- HEK293T
- In vitro E. coli expression system
- Mamanlian cells
- E.coli expression system
- His
- Non
- Myc&DDK
- GST
- Flag
- His&Fc&Avi
Involved Pathway
CYP3A4 involved in several pathways and played different roles in them. We selected most pathways CYP3A4 participated on our site, such as Aflatoxin B1 metabolism,Aflatoxin activation and detoxification,Benzo(a)pyrene metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP3A4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chemical carcinogenesis | ADH2-1,CYP1A1,UGT1A3,AHA-1,ADH5,GSTT2,NAT1,CYP2C38,GSTM2,CYP2C8 |
| Aflatoxin activation and detoxification | CYP1A2,ACY3.2,ACY3.1,ACY3,CYP3C1,GGT6,GGTLC1,DPEP2,CYP3A5,CYP2Y3 |
| Aflatoxin B1 metabolism | FAM84B,CYP1A2,PRKRA,CYP2A13 |
| Cytochrome P450 - arranged by substrate type | CYP4A11,CYP2U1,CYP2C18,CYP2B6,CYP11B1,CYP2C8,CYP2S1,FDX1,CYP4F22,FDX1L |
| Biological oxidations | CYP2AD3,AHCY,CYP1B1,CYP3A7-CYP3AP1,CYP2K22,POMCB,GLYATL1,GSTK1,ADH6,CYP2C8 |
| Benzo(a)pyrene metabolism | CYP1B1,AKR1C2,CYP1A1,AKR1A1,AKR1C4,FAM84B |
| Bile secretion | SLCO1B2,ATP1A3,ABCB11,SLC9A3,SLC22A8,NR0B2,ABCB1A,SLC9A1,SLCO1A4,Slc4a2 |
Protein Function
CYP3A4 has several biochemical functions, for example, aromatase activity,caffeine oxidase activity,enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP3A4 itself. We selected most functions CYP3A4 had, and list some proteins which have the same functions with CYP3A4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| taurochenodeoxycholate 6alpha-hydroxylase activity | FAM84B |
| vitamin D 24-hydroxylase activity | CYP1A1,FAM84B |
| testosterone 6-beta-hydroxylase activity | FAM84B,CYP3A41B,CYP3A41A,CYP3A25 |
| iron ion binding | ALOX5,HBB-BH1,ALOX5B.3,CYP2AA1,CYP2A12,CYP2AD3,CYP2P10,CYP4F3,HBQ1,LCN2 |
| steroid hydroxylase activity | CYP2C9,CYP2C8,CYP46A1,CYP2R1,CYP2AD2,CYP2D10,CYP46A1.3,CYP2F1,CYP2A7,CYP2P6 |
| caffeine oxidase activity | CYP1A2,FAM84B,CYP2C38,CYP2C39,CYP2C9 |
| enzyme binding | MAPK14,CSF3,PEX5,GNB2L1,ABCD1,TSPAN15,BIRC7,ZFP346,CAT,SELS |
| steroid binding | ESRRG,CYP21A1,ESR2B,HSD3B4,ESRRGB,NR3C2,PAQR7,HSD3B5,HSD11B2,PGRMC2 |
| monooxygenase activity | COQ6,CYP4V7,MOXD2,CYP2AA4,CYP3A7,CYP4A12A,CYP2K16,CYP2C54,CYP3A25,CYP2X9 |
Interacting Protein
CYP3A4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP3A4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP3A4.
PGRMC1;GK
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References
- Czerwinski, M; Kazmi, F; et al. Anti-CD28 Monoclonal Antibody-Stimulated Cytokines Released from Blood Suppress CYP1A2, CYP2B6, and CYP3A4 in Human Hepatocytes In Vitro. DRUG METABOLISM AND DISPOSITION 43:42-52(2015).
- Uehara, S; Murayama, N; et al. Immunochemical quantification of cynomolgus CYP2J2, CYP4A and CYP4F enzymes in liver and small intestine. XENOBIOTICA 45:124-130(2015).
