CYP2U1
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Official Full Name
cytochrome P450, family 2, subfamily U, polypeptide 1 -
Overview
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is a hydroxylase that metabolizes arachidonic acid, docosahexaenoic acid, and other long chain fatty acids. -
Synonyms
CYP2U1;cytochrome P450, family 2, subfamily U, polypeptide 1;cytochrome P450 2U1;CP2U1_HUMAN;CYP2U 1;EC 1.14.14.1;P450TEC
Recombinant Proteins
- Human
- Rat
- Mouse
- Zebrafish
- Mus musculus
- Bovine
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
Involved Pathway
CYP2U1 involved in several pathways and played different roles in them. We selected most pathways CYP2U1 participated on our site, such as Arachidonic acid metabolism,Biological oxidations,Cytochrome P450 - arranged by substrate type, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2U1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism of lipids and lipoproteins | MTF1,ARSK,ACOT12,ALOX5B.3,DHCR24,FABP9,APOBB.1,NEU4,CTGF,CPNE7 |
| Phase 1 - Functionalization of compounds | ADH8A,CYP3A7,CYP2K22,CYP2A7,CYP46A1,CYP2AD6,CYP2K18,CYP2N13,CYP2K8,CYP3C1 |
| Biological oxidations | CYP11B1,BPNT1,ADH1A,CYP2K6,CYP4F22,FAM84B,SULT4A1,CYP2V1,CYP4A11,UGT1B2 |
| Metabolic pathways | NADKA,AK7,MOCS1,AOX3L1,GMDS,CDIPT,AMT,ITGB1BP3,MAN1A2,CHIA.4 |
| Metabolism | G0S2,MED7,MED16,CYP2AD2,NUDT10,LMF1,CHST14,NAT2,CYP3C4,AHCY |
| Cytochrome P450 - arranged by substrate type | CYP2C18,FDX1L,POMCB,CYP2D6,CYP11B1,CYP3A7-CYP3AP1,CYP2AD3,CYP7A1,CYP4A11,FAM84B |
| Arachidonic acid metabolism | PTGIS,PTGESL,CYP2J6,CYP2AD2,GGT5A,MAPKAPK2B,CYP1A1,PLB1,GGTLC1,PLA2G4A |
| Miscellaneous substrates | CYP2K8,CYP2W1,CYP2K22,CYP3C1,CYP2S1,CYP2K19,CYP2K17,CYP4F11,CYP4F22,CYP2K6 |
Protein Function
CYP2U1 has several biochemical functions, for example, aromatase activity,heme binding,iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2U1 itself. We selected most functions CYP2U1 had, and list some proteins which have the same functions with CYP2U1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| steroid hydroxylase activity | CYP2J2,CYP2X10.2,CYP2AA2,CYP2C18,CYP2X8,CYP46A1.3,CYP2D26,CYP2K19,CYP2C55,CYP2B19 |
| oxygen binding | CYP2AA1,TDO2,CYP2C18,CYP2C37,HBA1,CYP2A6,CYP2Y3,CYP2K16,CYP2D10,CYP2K22 |
| iron ion binding | FTL,CYP2X10.2,CYP2R1,OGFOD2,SC5D,C14orf169,CYP4F11,CYP4F3,CYP2AA12,ALKBH8 |
| heme binding | CYP2C54,CYP51,CYP4A14,HBA-X,CYP3A5,HBAE3,HEBP1,HBD,CYP4F12,CYB5R4 |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | CYP2AA3,CYP2AA6,CYP2D26,CYP2AA1,CYP1B1,CYP2D10,CYP2AA7,CYP2X10.2,CYP2A6,CYP3C1 |
| aromatase activity | CYP3A25,CYP19A1,CYP2C9,CYP1B1,CYP2C37,CYP4F12,CYP2D6,FAM84B,CYP3A7,CYP3A5 |
Interacting Protein
CYP2U1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2U1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2U1.
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References
- Lopez-Vicario, C; Alcaraz-Quiles, J; et al. Inhibition of soluble epoxide hydrolase modulates inflammation and autophagy in obese adipose tissue and liver: Role for omega-3 epoxides. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112:536-541(2015).
- Wortmann, SB; Espeel, M; et al. Inborn errors of metabolism in the biosynthesis and remodelling of phospholipids. JOURNAL OF INHERITED METABOLIC DISEASE 38:99-110(2015).
