CYP19A1
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Official Full Name
cytochrome P450, family 19, subfamily A, polypeptide 1 -
Overview
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. The gene expresses two transcript variants. [provided by RefSeq, Jul 2008] -
Synonyms
CYP19A1;cytochrome P450, family 19, subfamily A, polypeptide 1;ARO;ARO1;CPV1;CYAR;CYP19;CYPXIX;P-450AROM;aromatase;estrogen synthase;estrogen synthetase;cytochrome P-450AROM;cytochrome P450 19A1;microsomal monooxygenase;flavoprotein-linked monooxygenase;cytochrome P450, subfamily XIX (aromatization of androgens)
Recombinant Proteins
- Human
- Chicken
- Mouse
- Rat
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- Non
- His
- GST
- Flag
- Avi
- Fc
- DDK
- Myc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CYP19A1-432H | Recombinant Human CYP19A1 protein | E.coli | Human | Non | 1 - 181 aa | |
| ARO-3637H | Recombinant Human ARO, His-tagged | E.coli | Human | His | 503 |
|
| CYP19A1-1157C | Recombinant Chicken CYP19A1 | Mammalian Cells | Chicken | His |
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| CYP19A1-145H | Recombinant Human CYP19A1 | Mammalian Cells | Human | His |
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| CYP19A1-158H | Recombinant Human CYP19A1 protein, GST-tagged | Wheat Germ | Human | GST | 48-218 a.a. |
|
| CYP19A1-26393TH | Recombinant Human CYP19A1 | Wheat Germ | Human | Non | 219 amino acids |
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| CYP19A1-26421TH | Recombinant Human CYP19A1 | Wheat Germ | Human | Non | 182 amino acids |
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| CYP19A1-4148M | Recombinant Mouse CYP19A1 Protein | Mammalian Cells | Mouse | His |
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| CYP19A1-7127HCL | Recombinant Human CYP19A1 293 Cell Lysate | HEK293 | Human | Non |
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| CYP19A1-0938H | Recombinant Human CYP19A1 protein, His-tagged | E.coli | Human | His | 1-503aa |
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| CYP19A1-112HF | Recombinant Full Length Human CYP19A1 Protein | In Vitro Cell Free System | Human | Full L. 219 amino acids |
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| CYP19A1-1732HFL | Recombinant Full Length Human CYP19A1 Protein, C-Flag-tagged | Mammalian Cells | Human | Flag | Full L. |
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| CYP19A1-1911H | Recombinant Human CYP19A1 Protein (Leu196-Val373), His tagged | E.coli | Human | His | Leu196-Val373 |
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| CYP19A1-2126M | Recombinant Mouse CYP19A1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| CYP19A1-2126M-B | Recombinant Mouse CYP19A1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| Cyp19a1-2411M | Recombinant Mouse Cyp19a1 Protein, Myc/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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| CYP19A1-300H | Recombinant Human CYP19A1 protein, GST-tagged | E.coli | Human | GST | 241-400 aa |
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| CYP19A1-301H | Recombinant Human CYP19A1 protein, His-tagged | E.coli | Human | His | 241-400 aa |
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| CYP19A1-302H | Recombinant Human CYP19A1 protein, His-tagged | E.coli | Human | His | 1-181 aa |
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| Cyp19a1-368M | Recombinant Mouse Cyp19a1 Protein, His-tagged | E.coli | Mouse | His | Leu196-Val373 |
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| Cyp19a1-369R | Recombinant Rat Cyp19a1 Protein, His-tagged | E.coli | Rat | His | Leu196-Val373 |
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| CYP19A1-548H | Recombinant Human CYP19A1 Protein, His-tagged | E.coli | Human | His | Leu196~Val373 |
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| CYP19A1-698H | Recombinant Human CYP19A1 Protein, His (Fc)-Avi-tagged | HEK293 | Human | Avi&Fc&His |
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| CYP19A1-698H-B | Recombinant Human CYP19A1 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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Involved Pathway
CYP19A1 involved in several pathways and played different roles in them. We selected most pathways CYP19A1 participated on our site, such as Biological oxidations,Cytochrome P450 - arranged by substrate type,Endogenous sterols, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP19A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytochrome P450 - arranged by substrate type | CYP3A7,CYP4B1,CYP21A2,CYP1B1,CYP11A1,CYP2K18,CYP2Y3,CYP11B1,CYP27A1,CYP2E1 |
| Metabolic pathways | GUSB,MAT2AL,ST6GALNAC4,NDST4,PIGS,FAHD1,PIGK,AKR1B1L,ADH2-2,NADKD1 |
| Biological oxidations | CYP2Y3,UGT1B4,SULT4A1,ADH8A,SULT1ST5,CYP2B6,CYP4T8,CYP1A1,GGTLC1,CYP3C4 |
| FSH signaling pathway | CGA,AREG |
| Metabolism | SLC2A3,APOEA,GLTP,TIMMDC1,APOA4A,NAT2,KCNC2,FABP12,ARL2BP,GLB1L |
| Endogenous sterols | FDXR,CYP17A1,FDX1,CYP21A2,CYP1B1,CYP27A1,FDX1L,CYP11A1,CYP11B2,CYP51A1 |
| Estrogen biosynthesis | AKR1B15,HSD17B11 |
| Integrated Breast Cancer Pathway | AHR,GDI1,ANXA1,DAG1,SMARCA4,UBE2F,ERAL1,NOXA1,RPP38,APOBEC3G |
Protein Function
CYP19A1 has several biochemical functions, for example, aromatase activity,electron carrier activity,heme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP19A1 itself. We selected most functions CYP19A1 had, and list some proteins which have the same functions with CYP19A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | CYP2F1,CYP3A25,CYP2E1,CYP2AA9,CYP2A4,CYP2AA8,CYP2K6,CYP2AA3,CYP2J6,CYP2F2 |
| electron carrier activity | GLRX2,FDX1L,IDH3B,PTGES2,GLRX,NQO2,NCF2,GLRX3,IVD,QDPR |
| heme binding | CYP2AA8,CYP4F2,XGB,CYP2Y3,MPO,CYP2X8,CYP3A25,CYP2P9,CYP2P6,TDO2 |
| iron ion binding | HBB,CYP1A,PLOD3,EGLN3,LEPRE1,FTL,HBA2,CYP2J6,FDX1,CYP4V7 |
| oxygen binding | CYP2A12,CYP4B1,CYP2C39,BA1,HBQ1,CYP2J6,CYP2AA9,CYP2K22,HBAE1,CYP2B19 |
| aromatase activity | CYP1B1,CYP2A12,CYP3A4,CYP2C54,CYP3A25,CYP2A13,CYP1D1,CYP2C55,CYP2J6,CYP2D26 |
Interacting Protein
CYP19A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP19A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP19A1.
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References
- Chourasia, TK; Pang, YF; et al. The Catecholestrogen, 2-Hydroxyestradiol-17beta, Acts as a G Protein-Coupled Estrogen Receptor 1 (GPER/GPR30) Antagonist to Promote the Resumption of Meiosis in Zebrafish Oocytes. BIOLOGY OF REPRODUCTION 92:-(2015).
- Reverchon, M; Bertoldo, MJ; et al. CHEMERIN (RARRES2) Decreases In Vitro Granulosa Cell Steroidogenesis and Blocks Oocyte Meiotic Progression in Bovine Species. BIOLOGY OF REPRODUCTION 90:-(2014).
