CXCR5
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Official Full Name
chemokine (C-X-C motif) receptor 5 -
Overview
This gene encodes a multi-pass membrane protein that belongs to the CXC chemokine receptor family. It is expressed in mature B-cells and Burkitts lymphoma. This cytokine receptor binds to B-lymphocyte chemoattractant (BLC), and is involved in B-cell migration into B-cell follicles of spleen and Peyer patches. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011] -
Synonyms
CXCR5;chemokine (C-X-C motif) receptor 5;BLR1;CD185;MDR15;C-X-C chemokine receptor type 5;CXC-R5;CXCR-5;MDR-15;monocyte-derived receptor 15;Burkitt lymphoma receptor 1, GTP-binding protein;Burkitt lymphoma receptor 1, GTP binding protein (chemokine (C-X-C motif) receptor 5)
Recombinant Proteins
- Human
- Rat
- Chicken
- Mouse
- HEK293
- Mammalian Cell
- In Vitro Cell Free System
- E.coli
- E.coli expression system
- Non
- His
- His&Flag
- GST
- His&Fc&Avi
- His&GST
Involved Pathway
CXCR5 involved in several pathways and played different roles in them. We selected most pathways CXCR5 participated on our site, such as Cytokine-cytokine receptor interaction,Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CXCR5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chemokine signaling pathway | GRB2,STAT3,GNB3,AKT1,CCL26,GNGT2,CCR9,CCL22,GNG7,PIK3CA |
| Cytokine-cytokine receptor interaction | IL-8,IL21R,LIF,CCR1L1,PDGFA,Ifnlr1,IL13,CX3CL1,IL2RB,IFNAR2 |
Protein Function
CXCR5 has several biochemical functions, for example, C-X-C chemokine receptor activity,G-protein coupled receptor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CXCR5 itself. We selected most functions CXCR5 had, and list some proteins which have the same functions with CXCR5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein coupled receptor activity | TACR3L,MRGPRX3,OPN1MW1,MGAA,TMTOPS3B,MRGPRD,TAAR12E,GPR97,GPR20,GPR81 |
| protein binding | ZFP143,UTP11L,INTS12,SOX5,C9orf116,MED22,NR2F2,PDE6H,NRF1,SYNJ2 |
| C-X-C chemokine receptor activity | CXCR4,CXCR7,CXCR6,CXCR3,CXCR4A,CXCR3.1,CCR9A,CXCR4B,CXCR2,CCBP2 |
Interacting Protein
CXCR5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CXCR5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CXCR5.
GNAI2;GNAO1;GNB3;GNAQ;CXCR4;GNA13
Resources
Research Area
B Cell CD AntigenChemokine Receptors
B Cell Chemotaxis, Migration, and Adhesion
Regulatory T Cells (Tregs)
T Cell Migration
T Follicular Helper (Tfh) Cells
CXC Chemokine Receptors
Related Services
Related Products
References
- Klimatcheva, E; Pandina, T; et al. CXCL13 antibody for the treatment of autoimmune disorders. BMC IMMUNOLOGY 16:-(2015).
- Spaan, M; Kreefft, K; et al. CD4(+)CXCR5(+) T cells in chronic HCV infection produce less IL-21, yet are efficient at supporting B cell responses. JOURNAL OF HEPATOLOGY 62:303-310(2015).
