CUX1

  • Official Full Name

    cut-like homeobox 1

  • Overview

    The protein encoded by this gene is a member of the homeodomain family of DNA binding proteins. It may regulate gene expression, morphogenesis, and differentiation and it may also play a role in the cell cycle progession. Several alternatively spliced transcript variants encoding different isoforms have been identified.

  • Synonyms

    CUX1;cut-like homeobox 1;cut (Drosophila) like 1 (CCAAT displacement protein) , cut like 1, CCAAT displacement protein (Drosophila) , CUTL1;protein CASP;CASP;CDP;CDP/Cut;CDP/Cux;CDP1;Clox;CUT;CUX;Cux/CDP;golgi integral membrane protein 6;GO

Recombinant Proteins

  • Human
  • Chicken
  • Mouse
  • Mus musculus
  • E.coli
  • Wheat Germ
  • Mammalian Cells
  • HEK293
  • GST
  • His
  • Non
  • DDK
  • Myc
Cat.# Product name Source (Host) Species Tag Protein Length Price
CUX1-11709H Recombinant Human CUX1, GST-tagged E.coli Human GST C-term-341a.a.
CUX1-3332H Recombinant Human CUX1 protein, His-tagged E.coli Human His 1-341 aa
CUX1-2139H Recombinant Human CUX1 Protein, GST-tagged Wheat Germ Human GST
CUX1-5492C Recombinant Chicken CUX1 Mammalian Cells Chicken His
CUX1-424HCL Recombinant Human CUX1 cell lysate Human Non
Cux1-2382M Recombinant Mouse Cux1 Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
CUX1-2756H Recombinant Human CUX1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
CUX1-301226H Recombinant Human CUX1 protein, GST-tagged E.coli Human GST Met1-Ser341
CUX1-3381H Recombinant Human CUX1 Protein, MYC/DDK-tagged HEK293 Human DDK&Myc
RFL26395MF Recombinant Full Length Mouse Protein Casp(Cux1) Protein, His-Tagged E.coli Mus musculus His Full L. Full Length (1-678)

    Involved Pathway

    CUX1 involved in several pathways and played different roles in them. We selected most pathways CUX1 participated on our site, such as Disease,Diseases of signal transduction,FGFR1 mutant receptor activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CUX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Disease MMAA,TH1L,TCEA1,CCDC167,OPN1SW,MTRR,MMADHC,TAF1L,FDX1,AP2A1
    Signaling by FGFR1 in disease CPSF6,TRIM24,FGFR1OP2,MYO18A
    Signaling by FGFR in disease CPSF6,FGFR1OP2,TRIM24,MYO18A,LRRFIP1
    FGFR1 mutant receptor activation CPSF6,FGFR1OP2,FGFR1OP,LRRFIP1,TRIM24,MYO18A
    Diseases of signal transduction OPN1MW,RBP1,CTBP2,FGFR1OP2,OS9,KREMEN2,DERL2,TNKS2,MIB1,TRIM24
    Signaling by FGFR1 fusion mutants MYO18A,FGFR1OP2,CPSF6,TRIM24

    Protein Function

    CUX1 has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding,chromatin binding,protein binding, bridging. Some of the functions are cooperated with other proteins, some of the functions could acted by CUX1 itself. We selected most functions CUX1 had, and list some proteins which have the same functions with CUX1. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II regulatory region sequence-specific DNA binding BARX2,FOXD3,CUX2,MYOG,POGZA,ZNF792,DMRT1,GATA6,PLAGL1,ZFAT
    chromatin binding NR5A1,MCMBP,KLHDC3,ARID5A,SSBP1,TOP1,EZH1,POU2F1,POLD1,HHEX
    sequence-specific DNA binding IRX5A,ENG2A,RORCA,RX1,HMX2,SCAND2P,PAX3A,PAX7,ISL1L,ZFP423
    transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding NFKB1,MEOX2,TARDBP,RELA,MIXL1,SPI1,SFPI1,PROP1,FUBP1,SIX6
    protein binding, bridging FSCN2B,FGB,STX1A,CBX5,CAV2,MEN1,ANK2,SH2D1B,NUFIP1,CAV1

    Interacting Protein

    CUX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CUX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CUX1.

    RB1;BIN1;CA12;RECQL5;MAX;q7cl32_yerpe;narX;ELAC2

    Resources

    Research Area

    Intracellular Signaling Molecules in Angiogenesis

    References

    • Gan, XT; Zhao, GJ; et al. Identification of Fat Mass and Obesity Associated (FTO) Protein Expression in Cardiomyocytes: Regulation by Leptin and Its Contribution to Leptin-Induced Hypertrophy. PLOS ONE 8:-(2013).
    • Ikeda, T; Kumagai, E; et al. Soluble CD26/Dipeptidyl Peptidase IV Enhances the Transcription of IL-6 and TNF-alpha in THP-1 Cells and Monocytes. PLOS ONE 8:-(2013).

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