CTSK
-
Official Full Name
cathepsin K -
Overview
The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. [provided by RefSeq, Apr 2013] -
Synonyms
CTSK;cathepsin K;CTSO;PKND;PYCD;CTS02;CTSO1;CTSO2;cathepsin O;cathepsin X;cathepsin O1;cathepsin O2
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Zebrafish
- Cattle
- Dog
- Mouse
- Pig
- Chicken
- Cynomolgus
- Rabbit
- E.coli
- Insect Cells
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- Yeast
- Non
- His
- GST
- His&GST
- His&Fc&Avi
- His&SUMO
Involved Pathway
CTSK involved in several pathways and played different roles in them. We selected most pathways CTSK participated on our site, such as Activation of Matrix Metalloproteinases,Adaptive Immune System,Collagen degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTSK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Extracellular matrix organization | DST,KLK7,COL13A1,BGNB,PCOLCEA,HAPLN1,MMP24,LAMC3,ELANE,COL9A3 |
| Innate Immune System | CLEC6A,BAIAP2,CFHL2,PELI2,DEFB116,SIGLEC15,DEFB125,CTS7,RNF216,POLR3GLA |
| Lysosome | NAGPA,CTSO,ATP6V1H,LAMP3,GNSB,DNASE2A,SMPD1,ABCB9,GBA,CTSLA |
| Adaptive Immune System | LILRB5,RAPGEF3,NCR3LG1,UBE2E3,ITGB1B.1,AP2A1,KIF18A,AP2M1,TRIM63,SRMS |
| Immune System | NPEPPS,ABI2,CD200R2,RNF216,RNF135,STIM1B,CLEC2H,CMTM2A,TRIM45,FAM49BA |
| Activation of Matrix Metalloproteinases | MMP8,MMP11,FURINB,TPSAB1,CTSL2,MMP17,CMA1,CTSLL,MGC174155,MMP24 |
| Collagen degradation | CTSB,MMP20,MGC174155,MGC174152,COL23A1,CTSD,COL13A1,CTS7,TLDC2,ADAM9 |
| Degradation of the extracellular matrix | COL9A1,COL19A1,COL15A1B,MMP24,LOC100686744,MMP20,ELANE,TPSAB1,BMP1,CTSL2 |
Protein Function
CTSK has several biochemical functions, for example, collagen binding,cysteine-type endopeptidase activity,cysteine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CTSK itself. We selected most functions CTSK had, and list some proteins which have the same functions with CTSK. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cysteine-type endopeptidase activity | USP24,USP47,CTSW,ATG4A,USP33,CTSL1,USP28,USP48,USP10,CASP9 |
| collagen binding | CTSB,Pdgfa&Pdgfb,SERPINH1B,HSD17B12,ITGA9,NID1,CTSS,CD44,ACHE,SMAD7 |
| fibronectin binding | MFAP2,IGFBP3,CTSS,MYOC,PLEKHA2,HSD17B12,ITGB1,LRRC15,LPA,IGFBP5A |
| protein binding | MPZL3,TAB1,CTBP2,PXMP4,PIH1D2,ZW10,RNF20,CBX5,STON2,FAM158A |
| cysteine-type peptidase activity | SENP3B,Ctsl,USPL1,CTSBB,CAPN8,CTSBA,CTSJ,CASPB,PSD,USP17L3 |
| proteoglycan binding | CECR1,NID1,FCN2,CTSL1,UBE4A,COL5A1,THBS1,CECR1A,CTSB,CTSS |
Interacting Protein
CTSK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTSK here. Most of them are supplied by our site. Hope this information will be useful for your research of CTSK.
srp-6;FGFR3;mexB
Resources
Research Area
Lysosomal EnzymesOther Secreted VSMC Molecules
Rheumatoid arthritis Therapeutic Targets
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References
