CTSH
-
Official Full Name
cathepsin H -
Overview
The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. -
Synonyms
CTSH;cathepsin H;CPSB;pro-cathepsin H;ACC 4;ACC 5;aleurain;cathepsin B3;cathepsin BA;N-benzoylarginine-beta-naphthylamide hydrolase;ACC-4;ACC-5;minichain;MGC1519;DKFZp686B24257
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Mouse
- E.coli
- CHO
- Human Liver
- Mammalian Cells
- Human liver
- Wheat Germ
- Human Cells
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- T7
- His&T7
- His&Fc&Avi
- Myc&DDK
Involved Pathway
CTSH involved in several pathways and played different roles in them. We selected most pathways CTSH participated on our site, such as Adaptive Immune System,Immune System,Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTSH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Surfactant metabolism | SLC34A2A,GATA6,ZDHHC2,CCDC59,SFTPBB,SFTPC,DMBT1,CKAP4,GPR116,LMCD1 |
| Immune System | KLRF1,SLAMF6,EIF4E3,DYNC1I2,AP1S1,EGR1,POLR3H,B2ML,CTSB,ACTR2B |
| Adaptive Immune System | UBE2J2,RNF41,CTSL1,LAIR2,EGF,UBA5,ASB11,AP2B1,NA,LILRA1 |
| MHC class II antigen presentation | KIF15,KIF26A,CTS7,CTSO,AP1S3A,OSBPL1A,RACGAP1,CTSE,FAM49BA,DYNC1I1 |
| Metabolism of proteins | TRAPPC9,MUC15,SPON1B,ASNA1,ARSE,EXOC3,SMC6,DCP2,SPON1A,CGB5 |
| Lysosome | PPT1,SORT1B,ATP6V0A2B,ACP5,CTSA,DNASE2A,AP3B2,CLTCA,GLA,SGSH |
Protein Function
CTSH has several biochemical functions, for example, HLA-A specific activating MHC class I receptor activity,aminopeptidase activity,cysteine-type endopeptidase activator activity involved in apoptotic process. Some of the functions are cooperated with other proteins, some of the functions could acted by CTSH itself. We selected most functions CTSH had, and list some proteins which have the same functions with CTSH. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| serine-type endopeptidase activity | CFD,PIK3IP1,IMMP1L,KEX2,PLAUB,KLK8,CELA3B,CELA1,MCPT8,PRSS45 |
| cysteine-type endopeptidase activity | CTSM,CASP3A,USP10,CTSK,CASP6,ATG4D,CTSL.1,CTSSA,USP43,CASP8L1 |
| protein binding | TRPM6,COG7,APPL2,RMND5A,KRTAP9-4,HYAL3,AVPI1,VSTM2L,PRPF8,MBNL3 |
| peptidase activity | TMPRSS11D,MMP14A,MALT1,NPEPPS,CAPN3,KLK7,GZME,USP43A,TMPRSS11G,SHHA |
| aminopeptidase activity | METAP1,ERAP2,TRHDE,Ctsl,ENPEP,XPNPEP1,XPNPEP3,LAP3,NPEPL1,PHEX |
| thyroid hormone binding | ALDH1A3,CRYM,THRA,THRB |
| cysteine-type peptidase activity | CASPA,SOLH,CAPN1B,CASPBL,CAPN2,CASP6,CASP8,USP12A,USP2A,USP9 |
| endopeptidase activity | FAP,SENP3B,TRAPPC12,PSMB11,ECE1,TPP1,TMEM59,PSMA7,HTRA4,KLK1B4 |
| cysteine-type endopeptidase activator activity involved in apoptotic process | NOD1,NLRP1,CARD8,GNB2L1,PYCARD,MAPK9,BAD,NLRP12,CTSC,RPS27L |
Interacting Protein
CTSH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTSH here. Most of them are supplied by our site. Hope this information will be useful for your research of CTSH.
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References
- Mahlios, J; De la Herran-Arita, AK; et al. The autoimmune basis of narcolepsy. CURRENT OPINION IN NEUROBIOLOGY 23:767-773(2013).
- Kiyamova, R; Garifulin, O; et al. Preliminary study of thyroid and colon cancers-associated antigens and their cognate autoantibodies as potential cancer biomarkers. BIOMARKERS 17:362-371(2012).
