CRYGD
-
Official Full Name
crystallin, gamma D -
Overview
Reumathoid arthritis (RA) is one of the most common autoimmune diseases (1-2% European population). The most significant clinical symptom is an inflammation of the synovial membranes which causes a painful swelling of the articulations and the ankylosis. In order to correctly diagnose RA it is necessary to exclude other forms of arthritis: in such a diagnostic process, the laboratory plays an important role in the determination of Rheumatoid Factor (RF) antibodies of class IgM, detectable in 60-80% of the patients with RA. The RF antibodies are sensitive but not very specific markers; on the contrary, anti-CCPs are characterized by a specificity of over 90% in patients affected by RA ,and are detectable in a very early asymptomatic stage in the approximately 70% of RA patients whereas only 2% of the control subjects resulted positive. Therefore, the presence of Anti-CCP antibodies can be used in the diagnosis of RA, particularly in the case of erosive arthritis, in childhood in the case of juvenile RA. The test also appears, to be useful in differentiating the collagen pathologies with concomitant arthritis from the RA. The Anti-CCP antibodies test has an important prognostic value in the monitoring of articular radiologically detectable damage. The kit’s quantitative determination is useful in the control and verification of the effects of pharmacological therapy. The Anti-CCP antibody test, together with the determination of RF, increases the ratio of sensitivity / specificity. 20% of the RAs are RF-negative and 15/20% of the RAs are positive only to RF. The simultaneous positive result of a sample to RF and CCP has a positive predictive value of about 100%. The levels of anti-CCP antibodies are not necessarily correlated to the evolutionary stage of the illness. The advantage of the anti-CCP antibodies is that they are detectable in the patient sera up to 10 years prior to the appearance of symptoms. In addition, in cases of early arthritis a positive test result, according to some studies is related to the development of bone erosive lesions of the articulations. -
Synonyms
CACA;CCA3;CCP;CRYG4;cry-g-D;gamma crystallin 4;gamma-D-crystallin;gamma-crystallin 4;gamma-crystallin D
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Mouse
- Bovine
- Human
- Mammalian Cell
- Wheat Germ
- E.coli
- HEK293
- Bovine eye lens
- HEK293T
- In Vitro Cell Free System
- His
- GST
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
CRYGD involved in several pathways and played different roles in them. We selected most pathways CRYGD participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CRYGD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
CRYGD has several biochemical functions, for example, protein binding,structural constituent of eye lens. Some of the functions are cooperated with other proteins, some of the functions could acted by CRYGD itself. We selected most functions CRYGD had, and list some proteins which have the same functions with CRYGD. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| structural constituent of eye lens | ASL2,CRYBB3,CRYBA4,LIM2.4,LIM2.2,ATXN1,CRYBB2,CRYAA,CRYGF,CRYGC |
| protein binding | IL17RE,KL,UFC1,RNF138,SCNN1D,TAC3,FARSA,LRRC3,SLC6A18,HIF1AN |
Interacting Protein
CRYGD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CRYGD here. Most of them are supplied by our site. Hope this information will be useful for your research of CRYGD.
Cryab;Cryaa
Resources
Related Services
Related Products
References
- Roberts, CJ; Blanco, MA; et al. Role of Anisotropic Interactions for Proteins and Patchy Nanoparticles. JOURNAL OF PHYSICAL CHEMISTRY B 118:12599-12611(2014).
- Dalakas, MC; et al. Mechanistic Effects of IVIg in Neuroinflammatory Diseases: Conclusions Based on Clinicopathologic Correlations. JOURNAL OF CLINICAL IMMUNOLOGY 34:S120-S126(2014).
