CRX
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Official Full Name
cone-rod homeobox -
Overview
The protein encoded by this gene is a photoreceptor-specific transcription factor which plays a role in the differentiation of photoreceptor cells. This homeodomain protein is necessary for the maintenance of normal cone and rod function. Mutations in this gene are associated with photoreceptor degeneration, Leber congenital amaurosis type III and the autosomal dominant cone-rod dystrophy 2. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. -
Synonyms
CRX;cone-rod homeobox;CORD2;cone-rod homeobox protein;CRD;LCA7;orthodenticle homeobox 3;OTX3;Cone rod homeobox;Cone rod homeobox protein;CORD 2;CRX_HUMAN;LCA 7;OTX 3;OTTHUMP00000244137;OTTHUMP00000244138;OTTHUMP00000244139
Recombinant Proteins
- Human
- Zebrafish
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- E. coli
- In Vitro Cell Free System
- His
- GST
- Non
- His&Myc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CRX-3854H | Recombinant Human CRX protein, His-tagged | E.coli | Human | His | 166-285 aa | |
| CRX-1919H | Recombinant Human CRX Protein, GST-tagged | Wheat Germ | Human | GST |
|
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| CRX-26342TH | Recombinant Human CRX | Wheat Germ | Human | Non | 299 amino acids |
|
| CRX-26343TH | Recombinant Human CRX | Wheat Germ | Human | Non | 95 amino acids |
|
| CRX-9413Z | Recombinant Zebrafish CRX | Mammalian Cell | Zebrafish | His |
|
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| CRX-7270HCL | Recombinant Human CRX 293 Cell Lysate | HEK293 | Human | Non |
|
|
| CRX-001H | Recombinant Human CRX Protein, His-tagged | E. coli | Human | His | 166-299 aa |
|
| CRX-2124HF | Recombinant Full Length Human CRX Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 299 amino acids |
|
| CRX-2671H | Recombinant Human CRX Protein (1-299 aa), His-Myc-tagged | E.coli | Human | His&Myc | 1-299 aa |
|
| CRX-93HF | Recombinant Full Length Human CRX Protein | In Vitro Cell Free System | Human | Full L. 299 amino acids |
|
Involved Pathway
CRX involved in several pathways and played different roles in them. We selected most pathways CRX participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CRX were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
CRX has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,chromatin binding,leucine zipper domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CRX itself. We selected most functions CRX had, and list some proteins which have the same functions with CRX. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | JUNBB,ZNF718,RBPJL,MEF2B,ARNT2,SOX10,PLAG1,BCL11A,ASCL2,YBX1 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | GABPA,ZNF750,MITF,POU4F1,HOXC13,NEUROD1,NDN,GATA3,TFAP2E,NR1H4 |
| leucine zipper domain binding | NRL,ATF4,AATF,DAPK3,KCNA3,PMF1,MKL1,ERC1,PAWR,DDIT3 |
| protein binding | SRGAP3,SREBF2,CSPP1,ACTR1B,WHSC1,HIF1AN,FBXO3,RAB3IP,2610109H07Rik,RPP25 |
| chromatin binding | CDC45,SOX9A,JARID2B,NCOA1,CBFA2T3,NPM2,OVOL2,BEND6,MORF4L1,HESX1 |
| nuclear hormone receptor binding | BUD31,ACTN4,CRY1,SIRT1,SMARCD3,CTNNB1,TACC2,HIF1A,MYOD1,SNW1 |
| transcription factor activity, sequence-specific DNA binding | NKX2,THRAA,OTX1B,TBX5B,PA2G4A,MYCN,FOXG1,ZNF668,HEY1,SPI1 |
Interacting Protein
CRX has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CRX here. Most of them are supplied by our site. Hope this information will be useful for your research of CRX.
ROR2;767;PRKAB2;GCM2;STK16
Resources
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References
- Liu, Y; Zhong, XF; et al. p16(INK4a) expression in retinoblastoma: a marker of differentiation grade. DIAGNOSTIC PATHOLOGY 9:-(2014).
- Maroof, A; Yorgensen, YM; et al. Intranasal Vaccination Promotes Detrimental Th17Mediated Immunity against Influenza Infection. PLOS PATHOGENS 10:-(2014).
