CRTC3
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Official Full Name
CREB regulated transcription coactivator 3
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Overview
This gene is a member of the CREB regulated transcription coactivator gene family. This family regulates CREB-dependent;gene transcription in a phosphorylation-independent manner and may be selective for cAMP-responsive genes. The protein;encoded by this gene may induce mitochondrial biogenesis and attenuate catecholamine signaling in adipose tissue. A;translocation event between this gene and Notch coactivator mastermind-like gene 2, which results in a fusion protein,;has been reported in mucoepidermoid carcinomas. Alternative splicing results in multiple transcript variants that;encode different protein isoforms. -
Synonyms
CRTC3; CREB regulated transcription coactivator 3; CREB-regulated transcription coactivator 3; FLJ21868; TORC-3; transducer of CREB protein 3; transducer of regulated CREB protein 3; transducer of regulated cAMP response element-binding protein 3; transdu;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- E.coli
- HEK293
- Mammalian Cell
- Wheat Germ
- GST
- His
- Fc
- Avi
- T7
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | CRTC3-32H | Recombinant Human CRTC3 protein, GST-tagged | Wheat Germ | GST | 176-274 |
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| Human | CRTC3-1114H | Recombinant Human CRTC3 protein, His & T7-tagged | E.coli | His&T7 | Met1~Phe103 |
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| Human | CRTC3-2207H | Recombinant Human CRTC3 Protein (Met1-Phe103), N-GST tagged | E.coli | GST | Met1-Phe103 |
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| Mouse | CRTC3-3928M | Recombinant Mouse CRTC3 Protein | Mammalian Cell | His |
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| Mouse | CRTC3-1992M-B | Recombinant Mouse CRTC3 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Mouse | CRTC3-1992M | Recombinant Mouse CRTC3 Protein, His (Fc)-Avi-tagged | HEK293 | His&Fc&Avi |
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- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
CRTC3 involved in several pathways and played different roles in them. We selected most pathways CRTC3 participated on our site, such as HTLV-I infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with CRTC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HTLV-I infection | HLA-E;FOSL1;FZD8;CCND3;SLC25A4;CD3E;WNT1;WNT3A;MAP2K4 |
CRTC3 has several biochemical functions, for example, cAMP response element binding protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CRTC3 itself. We selected most functions CRTC3 had, and list some proteins which have the same functions with CRTC3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cAMP response element binding protein binding | CRTC2;CREB3;CRTC1A;CRTC3;DDIT3;CREM;CRTC1;ATF2;KCNA3 |
CRTC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CRTC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CRTC3.
Research Area
Related articles
- Reviews
- Q&As
Customer Reviews (3)
Write a reviewThe CRTC3 protein's versatility extends beyond its use in vitro experiments.
With the CRTC3 protein as a research tool, achieving meaningful scientific findings becomes an accessible and achievable goal.
Their expertise and dedication enable them to effectively address and resolve any technical issues that may arise during experimentation.
Q&As (5)
Ask a questionModulating CRTC3 activity has shown promise as a potential therapeutic approach for treating metabolic diseases, though more research is needed.
CRTC3 is involved in glucose homeostasis by influencing the expression of genes related to gluconeogenesis and glucose uptake.
Research suggests that targeting CRTC3 may have therapeutic potential in certain cancers, but further studies are required to validate this approach.
The potential diagnostic applications of CRTC3 are still under exploration, but its altered expression levels may serve as biomarkers for certain conditions.
Modulating CRTC3 activity may hold promise for neuroprotective strategies, but the specific mechanisms and applications require more investigation.
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