CRLF1
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Official Full Name
cytokine receptor-like factor 1 -
Overview
This gene encodes a member of the cytokine type I receptor family. The protein forms a secreted complex with cardiotrophin-like cytokine factor 1 and acts on cells expressing ciliary neurotrophic factor receptors. The complex can promote survival of neuronal cells. Mutations in this gene result in Crisponi syndrome and cold-induced sweating syndrome. -
Synonyms
CRLF1;cytokine receptor-like factor 1;CISS;CISS1;CLF;CLF 1;cold induced sweating syndrome;CISS 1;CLF1;CRLF 1;Cytokine like factor 1;Cytokine receptor like factor 1;NR 6;NR6;ZcytoR 5;ZcytoR5;cytokine-like factor 1;class I cytokine receptor;cytokine type 1 receptor CRLP-1;CLF-1
Recombinant Proteins
- Human
- Mouse
- E.coli
- Mammalian Cell
- Human Cell
- Wheat Germ
- HEK293
- Insect Cell
- In Vitro Cell Free System
- His&GST
- His&T7
- Fc
- GST
- His
- Non
- His&Fc&Avi
- His&Myc
Involved Pathway
CRLF1 involved in several pathways and played different roles in them. We selected most pathways CRLF1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CRLF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
CRLF1 has several biochemical functions, for example, contributes_to ciliary neurotrophic factor receptor binding,contributes_to cytokine activity,cytokine binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CRLF1 itself. We selected most functions CRLF1 had, and list some proteins which have the same functions with CRLF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to cytokine activity | IL12A,IL12B,CLCF1 |
| cytokine binding | Fzd4,IFNGR1,CSF1R,CSF1RA,KITA,NOG,PARK7,GBP1,CNTFR,KIT |
| contributes_to ciliary neurotrophic factor receptor binding | CLCF1 |
| protein heterodimerization activity | HIST1H2BO,BTBD11,ABTB2,GM5506,ATF4,NFYBB,NEUROD2,SOX17,CEBPG,RRAGD |
| protein binding | EDARADD,NOTCH2,DIAP1,CNNM3,DRAXIN,TREX1,HOXA10,CSNK1E,TCF3,ATG16L1 |
| receptor activity | FAS,CD2,TREM1,ITGB3A,P2RY1,CD1D,NOTCH4,RTN4RL1,SELS,LDLR |
Interacting Protein
CRLF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CRLF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CRLF1.
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