COX6C
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Official Full Name
cytochrome c oxidase subunit VIc -
Overview
Cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIc, which has 77% amino acid sequence identity with mouse subunit VIc. This gene is up-regulated in prostate cancer cells. A pseudogene has been found on chromosomes 16p12. -
Synonyms
COX6C;cytochrome c oxidase subunit VIc;cytochrome c oxidase subunit 6C;cytochrome c oxidase polypeptide VIc;cytochrome c oxidase subunit VIc preprotein
Recombinant Proteins
- Human
- Rat
- Mouse
- Chicken
- Zebrafish
- Rhesus macaque
- Bovine
- Saimiri sciureus (Common squirrel monkey)
- Macaca silenus (Lion-tailed macaque)
- Vicugna pacos (Alpaca) (Lama pacos)
- Trachypithecus cristatus (Silvered leaf-monkey) (Presbytis cristata)
- Mus musculus
- Pongo Pygmaeus
- Nycticebus coucang (Slow loris)
- Plecturocebus donacophilus (Bolivian gray titi monkey) (Callicebus donacophilus)
- Sus scrofa (Pig)
- Tarsius syrichta (Philippine tarsier)
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- Avi
- Fc
- DDK
- Myc
Involved Pathway
COX6C involved in several pathways and played different roles in them. We selected most pathways COX6C participated on our site, such as Alzheimers disease,Cardiac muscle contraction,Electron Transport Chain, which may be useful for your reference. Also, other proteins which involved in the same pathway with COX6C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Gene Expression | LSM11,TRIM33,ZNF225,IGF2BP2,POLR3F,TRMT44,ZNF658,HNRNPA2B1,TYW1,PAPOLA |
| Cardiac muscle contraction | CACNG8,TNNC1B,CACNB4,CACNG2,ATP1A3B,UQCRB,COX6A1,TNNI3,CACNA2D4,COX7A2 |
| Metabolic pathways | ALDH9A1A.1,ACSM4,ACLYA,GALNTL5,PKM,UQCRC1,FUT8,ATP6V1A,DHODH,RRM1 |
| Electron Transport Chain | COX17,COX7A2,COX11,COX5B,COX6B1,ATP5L,COX15,COX7C,UCP3,COX8A |
| Metabolism | AMDHD1,EBP,LYVE1,GC,PLD6,MED29,FA2H,SLC25A13,SLC25A1A,ATP5S |
| Alzheimers disease | ATP5B,BACE1,TNF,MAPT,COX7B,APP,COX6A1,COX7A2L,BAD,MAPK3 |
| Generic Transcription Pathway | ZNF596,ZNF498,ZNF738,ZNF483,ZNF777,ZNF167,ZNF839,ZNF620,ZNF554,ZNF684 |
| Huntingtons disease | DNAI1,COX4I2,POLR2D,SP1,ATP5F1,SIN3A,NDUFA1,NDUFB1,UQCRC2,ATP5O |
Protein Function
COX6C has several biochemical functions, for example, cytochrome-c oxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by COX6C itself. We selected most functions COX6C had, and list some proteins which have the same functions with COX6C. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytochrome-c oxidase activity | COX7A2L,COX11,COX7A2A,COX8A,COX15,COX7A3,COX7A2,SURF1,COX7B,CYB5A |
Interacting Protein
COX6C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COX6C here. Most of them are supplied by our site. Hope this information will be useful for your research of COX6C.
MT-CO2;GTF2F2;PHB;PTN;RCHY1;NDUFB8;MT-CO1;COX5A;HTT;CRK;CAPZA2;UQCRFS1;RAB2A;COX6A2;SURF1;LRRK2;P;TIMM21
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References
- Rahman, S; Taanman, JW; et al. A missense mutation of cytochrome oxidase subunit II causes defective assembly and myopathy. AMERICAN JOURNAL OF HUMAN GENETICS 65:1030-1039(1999).
- Ren, JC; Rebrin, I; et al. Cytochrome c oxidase loses catalytic activity and structural integrity during the aging process in Drosophila melanogaster. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 401:64-68(2010).
