COPS5
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Official Full Name
COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis) -
Overview
Jun activation domain-binding protein-1 (JAB1) also designated COP9 subunits 5 (COPS5) or SGN5 is a coactivator of AP-1 transcription factor that also promotes degradation of the cyclin-dependent kinase inhibitor p27Kip1. JAB1 interacts with c-Jun AP-1 containing complexes, and enhances transactivation from AP-1-dependent promoters. JAB1 is highly conserved in evolution and is widely expressed in mammalian tissues. It is localized both the nucleus and the cytoplasm. -
Synonyms
COPS5;COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis);COP9 (constitutive photomorphogenic, Arabidopsis, homolog) subunit 5;COP9 signalosome complex subunit 5;CSN5;JAB1;MOV 34;SGN5;38 kDa Mov34 homolog;signalosome subunit 5;jun activation domain-binding protein 1;MOV-34;MGC3149
Recombinant Proteins
- Zebrafish
- Human
- Chicken
- Mouse
- Rhesus macaque
- Mammalian Cell
- Wheat Germ
- E.coli
- HEK293
- Mammalian cells
- In Vitro Cell Free System
- HEK293T
- His
- GST
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
COPS5 involved in several pathways and played different roles in them. We selected most pathways COPS5 participated on our site, such as DNA Damage Recognition in GG-NER,DNA Repair,Formation of TC-NER Pre-Incision Complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with COPS5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HIF-1-alpha transcription factor network | ADM,CITED2,GATA2,EGLN3,TFF3,CP,NDRG1,PLIN2,ENG,NPM1 |
| Global Genome Nucleotide Excision Repair (GG-NER) | ACTL6A,ACTR5,INO80,CHD1L,PARP2,USP45,YY1,COPS3,DDB2,INO80C |
| Formation of TC-NER Pre-Incision Complex | PPIE,GPS1,DDB1,COPS7A,COPS4,COPS6,COPS8,COPS3,TCEA1,ERCC8 |
| DNA Damage Recognition in GG-NER | YY1A,ACTR5,PARP2,CETN2,COPS2,DDB1,INO80C,INO80,INO80B,MCRS1 |
| Hypoxic and oxygen homeostasis regulation of HIF-1-alpha | HIF3A,GNB2L1,NAA10,HIF1AN |
| TGF-beta Receptor Signaling Pathway | GIPC1,TGFBR3,ENG,ZEB1B,NFYBB,STK11IP,SKIA,ZEB2A,CTCF,ACVRL1 |
| DNA Repair | COPS4,POLI,PPP4CA,SMARCA5,RAD18,EME2,THRSP,TOPBP1,ZBTB32,GPS1 |
| Nucleotide Excision Repair | LIG1,ERCC3,COPS2,RBX1,USP45,ACTR5,CUL4A,INO80C,POLE2,POLD1 |
Protein Function
COPS5 has several biochemical functions, for example, metal ion binding,metallopeptidase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COPS5 itself. We selected most functions COPS5 had, and list some proteins which have the same functions with COPS5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metallopeptidase activity | ADAMTS4,ANPEPA,ADAM1B,CLCA3,ADAM10B,CNDP2,ADAM28,ADAM17,GM12824,ADAM9 |
| ubiquitin-specific protease activity | USP9,USP37,USP17L5,USP9X,USP6,OTUB1,USP19,USP44,ATXN3,MYSM1 |
| metal ion binding | ATP1A4,ZBTB3,ENO2,PPP2R3C,ZNF189,TRIM35-31,PON2,C1GALT1,NDUFS7,PFKL |
| transcription coactivator activity | TAF12,JUNBB,GTF2F1,SMARCA2,ATXN7L3,HAND1,MED16,SCAND1,YY1,MED20 |
| translation initiation factor activity | EIF3S10,EIF2S1,EIF3BA,EIF4E3,EIF4A1B,EIF5B,EIF2S2,EIF4A1A,EIF4E,EIF2S1A |
| protein binding | MINOS1,ADAP1,MEN1,RAB24,TRAIP,ITGA2,KLC1,OPA1,ASNA1,DPYSL3 |
Interacting Protein
COPS5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COPS5 here. Most of them are supplied by our site. Hope this information will be useful for your research of COPS5.
COPS3;GPS1;CUL4B;COPS6
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References
- Rajan, KE; Rajkumar, R; et al. Light-induced COP9 signalosome expression in the Indian false vampire bat Megaderma lyra. JOURNAL OF PHYSIOLOGICAL SCIENCES 60:43-49(2010).
- Oron, E; Mannervik, M; et al. COP9 signalosome subunits 4 and 5 regulate multiple pleiotropic pathways in Drosophila melanogaster. DEVELOPMENT 129:4399-4409(2002).
