COPS4
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Official Full Name
COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis) -
Overview
This gene encodes one of eight subunits composing COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. -
Synonyms
COPS4;COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis);COP9 (constitutive photomorphogenic, Arabidopsis, homolog) subunit 4;COP9 signalosome complex subunit 4;CSN4;SGN4;signalosome subunit 4;JAB1-containing signalosome subunit 4
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Chicken
- Mouse
- Rhesus macaque
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- Avi
- Fc
- DDK
- Myc
Involved Pathway
COPS4 involved in several pathways and played different roles in them. We selected most pathways COPS4 participated on our site, such as DNA Damage Recognition in GG-NER,DNA Repair,Formation of TC-NER Pre-Incision Complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with COPS4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| DNA Repair | PPP4CB,UBE2L6,KIAA0146,ZBTB32,PPIE,KDM4B,BARD1,POLI,HUS1,UBE2V2 |
| Formation of TC-NER Pre-Incision Complex | ERCC8,TCEA1,GPS1,COPS5,DDB1,ZFP830,COPS7B,COPS8,COPS3,ZNF830 |
| Global Genome Nucleotide Excision Repair (GG-NER) | COPS7A,COPS2,NFRKB,USP45,YY1,COPS3,INO80C,GPS1,COPS8,TFPT |
| Transcription-Coupled Nucleotide Excision Repair (TC-NER) | PPIE,COPS6,ERCC8,ZNF830,COPS7A,KIAA1530,GPS1,COPS7B,ZFP830,COPS3 |
| Nucleotide Excision Repair | RAD23AA,RAD23AB,XPA,COPS5,RFC2,ERCC6,NFRKB,USP45,ERCC4,CUL4A |
| DNA Damage Recognition in GG-NER | COPS6,YY1,INO80,ACTR5,DDB2,INO80B,PARP1,COPS7A,TFPT,DDB1 |
Protein Function
COPS4 has several biochemical functions, for example, contributes_to NEDD8-specific protease activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COPS4 itself. We selected most functions COPS4 had, and list some proteins which have the same functions with COPS4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | APC,UBR2,PRKDC,SEPT3,TEAD1,SNRPD1,REV1,EFS,SCGB2A2,C4BPA |
Interacting Protein
COPS4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COPS4 here. Most of them are supplied by our site. Hope this information will be useful for your research of COPS4.
USHBP1;Dtl;Ddb1;COPS5;CUL4B;FOS;C19orf57;vpr;ARF6;YWHAZ
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