COL3A1
-
Official Full Name
collagen, type III, alpha 1 -
Overview
This gene encodes the pro-alpha1 chains of type III collagen, a fibrillar collagen that is found in extensible connective tissues such as skin, lung, uterus, intestine and the vascular system, frequently in association with type I collagen. Mutations in this gene are associated with Ehlers-Danlos syndrome types IV, and with aortic and arterial aneurysms. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008] -
Synonyms
COL3A1;collagen, type III, alpha 1;EDS4A;collagen alpha-1(III) chain;collagen, fetal;alpha1 (III) collagen;Ehlers-Danlos syndrome type IV, autosomal dominant
Recombinant Proteins
- Human
- Mouse
- Rat
- Chicken
- Rhesus macaque
- Bovine
- P.pastoris
- HEK293
- Mammalian Cells
- Wheat Germ
- E.coli
- Human Placenta
- Bovine placenta
- Bovine (calf ) skin
- In Vitro Cell Free System
- Synthetic
- Yeast
- Non
- His
- GST
- DDK
- Myc
- Avi
- Fc
- Flag
Involved Pathway
COL3A1 involved in several pathways and played different roles in them. We selected most pathways COL3A1 participated on our site, such as Amoebiasis,Assembly of collagen fibrils and other multimeric structures,Binding and Uptake of Ligands by Scavenger Receptors, which may be useful for your reference. Also, other proteins which involved in the same pathway with COL3A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Collagen formation | LOXL3,COL10A1,COL19A1,COL4A4,COL25A1,COL9A3,CRTAP,COL8A1,LEPREL1,TLDC2 |
| ECM-receptor interaction | COL6A6,ITGA1,Npnt,GP6,GP1BA,COL5A1,TNC,SDC4,GP9,ITGB8 |
| Collagen biosynthesis and modifying enzymes | TLL2,EMID2,LEPRE1,COL10A1A,COL1A1,SERPINH1B,PCOLCEA,COL13A1,PRP,COL4A4 |
| Binding and Uptake of Ligands by Scavenger Receptors | COL1A2,HYOU1,SCGB3A2,HPX,STAB2,AMBP,SAA1,IGKC,LOC479668,COL1A1 |
| Amoebiasis | FN1,IL1B,IFNG,SERPINB6B,LAMA2,PLCB4,RAB7B,LAMB1,COL2A1,COL4A6 |
| Endothelins | EDNRB,EDN3,COL1A2,EDNRA,EDN2,EDN1,CYSLTR1 |
| Extracellular matrix organization | FBLN1,FBN2,COL28A1A,ITGB3A,COL11A1B,COL6A1,ADAMTS1,NID2,SERPINH1,COL2A1 |
| Assembly of collagen fibrils and other multimeric structures | LOX,COL11A1B,COL4A5,MMP13,BMP1A,COL8A1A,PCOLCE,ABHD1,COL5A3A,CTSS |
Protein Function
COL3A1 has several biochemical functions, for example, SMAD binding,extracellular matrix structural constituent,integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COL3A1 itself. We selected most functions COL3A1 had, and list some proteins which have the same functions with COL3A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| extracellular matrix structural constituent | COL2A1B,COL27A1B,ELNA,LAMB1,LAMA4,PRELP,KAL1,MEPE,MUC5AC,FBLN2 |
| integrin binding | MMP14,TSPAN4,PXN,VWF,LAMB2,CD9,FN1,FAP,ITGA5,ADAM17 |
| protein binding | SCYL2,TEX19.1,FRA10AC1,SYCE1,ALOX5AP,FLAD1,CRY1,C5orf20,USP5,BCL2L14 |
| platelet-derived growth factor binding | PDGFB,COL5A1,PDGFRB,PDGFRA,PDGFA,COL1A2,COL1A1,Pdgfa&Pdgfb,COL6A1,COL4A1 |
| SMAD binding | CREBBP,SMAD2,BMP2,CTNNB1,BMPR1B,EP300,FKBP1A,AXIN1,EID2,ACVRL1 |
| metal ion binding | ZBED4,ZNF548,ZFP771,MTMR4,BRIP1,AGAP5,WBP7,LMO7A,ZNF280C,ZNF502 |
Interacting Protein
COL3A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COL3A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of COL3A1.
all3_aedae;zwf;LOX;ispH;lcrS;pdpD2;q5nfa1_fratt;galT;pbpG;htrE;nagE;opuD;mutTA;thiF;katB;rpoB;q81vw1_bacan;q8ckb2_yerpe;mutY
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References
- Hung, CF; Rohani, MG; et al. Role of IGF-1 pathway in lung fibroblast activation. RESPIRATORY RESEARCH 14:-(2013).
- Vittal, R; Mickler, EA; et al. Type V Collagen Induced Tolerance Suppresses Collagen Deposition, TGF-beta and Associated Transcripts in Pulmonary Fibrosis. PLOS ONE 8:-(2013).
